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2016 ; 8
(7
): 544-7
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Posterior Reversible Encephalopathy Syndrome in Henoch-Schonlein Purpura and
Hemolytic Uremic Syndrome
#MMPMID27298664
Fidan K
; Kandur Y
; Ucar M
; Gucuyener K
; Soylemezoglu O
J Clin Med Res
2016[Jul]; 8
(7
): 544-7
PMID27298664
show ga
Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological
syndrome, composed of symptoms such as headache, seizures, visual disturbances,
lethargy, confusion, stupor, focal neurologic findings and radiological findings
of bilateral gray and white matter abnormalities suggestive of edema in the
posterior regions of the cerebral hemispheres. PRES is associated with
significant morbidity and mortality if it is not expeditiously recognized.
Magnetic resonance image (MRI) represents the most sensitive imaging technique
for recognizing PRES. PRES has been seen in various clinical settings including
renal disorders such as acute glomerulonephritis, lupus nephritis, nephrotic
syndrome, and drug usage such as calcineurin inhibitors. We aimed to present two
study cases for such clinical setting. In this report, we present two patients
with PRES in whom the primary diagnosis was hemolytic uremic syndrome (HUS) and
Henoch-Schonlein purpura (HSP). Both of them were treated with anticonvulsant and
proper antihypertensive drugs. A repeated MRI scan of the head, an ophthalmologic
assessment, and a follow-up electroencephalogram produced normal results with no
sequelae. Early recognition of PRES as a complication during different diseases
and therapies in childhood may facilitate the appropriate treatment, so that
intensive treatment should be performed as soon as possible to avoid neurological
sequelae.