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10.1158/0008-5472.CAN-12-3342 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-12-3342 C4893961!4893961!23856246     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2013 ; 73 (14): 4372-82 Nephropedia Template TP {{tp|p=23856246|t=2013. The Exomes of the NCI-60 Panel: a Genomic Resource for Cancer Biology and Systems Pharmacology |pdf=|usr=}}{{23856246}} gab.com Text The Exomes of the NCI-60 Panel: a Genomic Resource for Cancer Biology and Systems Pharmacology JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=23856246 #FOAvip The NCI-60 cell lines are the most frequently studied human tumor cell lines in cancer research. This panel has generated the most extensive cancer pharmacology database worldwide. In addition, these cell lines have been intensely investigated, providing a unique platform for hypothesis driven research focused on enhancing our understanding of tumor biology. Here, we report a comprehensive analysis of coding variants in the NCI-60 panel of cell lines identified by whole exome sequencing (WES), providing a list of possible cancer specific variants for the community. Furthermore, we identify pharmacogenomic correlations between specific variants in genes like TP53, BRAF, ERBBs and ATAD5 and anti-cancer agents such as nutlin, vemurafenib, erlotinib and bleomycin demonstrating one of many ways the data could be utilized to validate and generate novel hypotheses for further investigation. As new cancer genes are identified through large-scale sequencing studies, the data presented here for the NCI-60 will be an invaluable resource for identifying cell lines with mutations in such genes for hypothesis driven research. To enhance the utility of the data for the greater research community, the genomic variants are freely available in different formats and from multiple sources including the CellMiner and Ingenuity websites. Twit Text FOAVip The Exomes of the NCI-60 Panel: a Genomic Resource for Cancer Biology and Systems Pharmacology ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=23856246 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23856246 #FOAvip English Wikipedia <ref>{{Cite pmid|23856246}}</ref> The Exomes of the NCI-60 Panel: a Genomic Resource for Cancer Biology and Systems Pharmacology #MMPMID23856246 Abaan OD; Polley EC; Davis SR; Zhu YJ; Bilke S; Walker RL; Pineda M; Gindin Y; Jiang Y; Reinhold WC; Holbeck SL; Simon RM; Doroshow JH; Pommier Y; Meltzer PS Cancer Res 2013[Jul]; 73 (14): 4372-82 PMID23856246show ga The NCI-60 cell lines are the most frequently studied human tumor cell lines in cancer research. This panel has generated the most extensive cancer pharmacology database worldwide. In addition, these cell lines have been intensely investigated, providing a unique platform for hypothesis driven research focused on enhancing our understanding of tumor biology. Here, we report a comprehensive analysis of coding variants in the NCI-60 panel of cell lines identified by whole exome sequencing (WES), providing a list of possible cancer specific variants for the community. Furthermore, we identify pharmacogenomic correlations between specific variants in genes like TP53, BRAF, ERBBs and ATAD5 and anti-cancer agents such as nutlin, vemurafenib, erlotinib and bleomycin demonstrating one of many ways the data could be utilized to validate and generate novel hypotheses for further investigation. As new cancer genes are identified through large-scale sequencing studies, the data presented here for the NCI-60 will be an invaluable resource for identifying cell lines with mutations in such genes for hypothesis driven research. To enhance the utility of the data for the greater research community, the genomic variants are freely available in different formats and from multiple sources including the CellMiner and Ingenuity websites. äThe Exomes of the NCI-60 Panel: a Genomic Resource for Cancer Biology (epmc).pdf DeepDyve Pubget Overpricing