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10.4049/jimmunol.1501523 http://scihub22266oqcxt.onion/10.4049/jimmunol.1501523 C4893906!4893906 !27183584     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27183584 &cmd=llinks): Failed to open stream: HTTP request failed! 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Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production |pdf=|usr=}}{{27183584 }} gab.com Text Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27183584 #FOAvip T cells from patients with systemic lupus erythematosus (SLE) display a number of abnormalities, including increased early signaling events following engagement of the TCR. Signaling lymphocytic activation molecule family cell surface receptors and the X-chromosome-defined signaling lymphocytic activation molecule-associated protein (SAP) adaptor are important in the development of several immunocyte lineages and modulating the immune response. We present evidence that SAP protein levels are decreased in T cells and in their main subsets isolated from 32 women and three men with SLE, independent of disease activity. In SLE T cells, SAP protein is also subject to increased degradation by caspase-3. Forced expression of SAP in SLE T cells normalized IL-2 production, calcium (Ca(2+)) responses, and tyrosine phosphorylation of a number of proteins. Exposure of normal T cells to SLE serum IgG, known to contain anti-CD3/TCR Abs, resulted in SAP downregulation. We conclude that SLE T cells display reduced levels of the adaptor protein SAP, probably as a result of continuous T cell activation and degradation by caspase-3. Restoration of SAP levels in SLE T cells corrects the overexcitable lupus T cell phenotype. Twit Text FOAVip Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27183584 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27183584 #FOAvip English Wikipedia <ref>{{Cite pmid|27183584 }}</ref> Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production #MMPMID27183584 Karampetsou MP ; Comte D ; Kis-Toth K ; Terhorst C ; Kyttaris VC ; Tsokos GC J Immunol 2016[Jun]; 196 (12 ): 4915-24 PMID27183584 show ga T cells from patients with systemic lupus erythematosus (SLE) display a number of abnormalities, including increased early signaling events following engagement of the TCR. Signaling lymphocytic activation molecule family cell surface receptors and the X-chromosome-defined signaling lymphocytic activation molecule-associated protein (SAP) adaptor are important in the development of several immunocyte lineages and modulating the immune response. We present evidence that SAP protein levels are decreased in T cells and in their main subsets isolated from 32 women and three men with SLE, independent of disease activity. In SLE T cells, SAP protein is also subject to increased degradation by caspase-3. Forced expression of SAP in SLE T cells normalized IL-2 production, calcium (Ca(2+)) responses, and tyrosine phosphorylation of a number of proteins. Exposure of normal T cells to SLE serum IgG, known to contain anti-CD3/TCR Abs, resulted in SAP downregulation. We conclude that SLE T cells display reduced levels of the adaptor protein SAP, probably as a result of continuous T cell activation and degradation by caspase-3. Restoration of SAP levels in SLE T cells corrects the overexcitable lupus T cell phenotype. |*Lymphocyte Activation [MESH] |*Signal Transduction [MESH] |Adult [MESH] |Aged [MESH] |Calcium/metabolism [MESH] |Caspase 3/metabolism [MESH] |Down-Regulation [MESH] |Female [MESH] |Humans [MESH] |Immunoglobulin G/immunology [MESH] |Interleukin-2/*biosynthesis/immunology [MESH] |Lupus Erythematosus, Systemic/blood/*immunology/physiopathology [MESH] |Male [MESH] |Middle Aged [MESH] |Phosphorylation [MESH] |Receptors, Antigen, T-Cell/immunology [MESH] |Signaling Lymphocytic Activation Molecule Associated Protein/genetics/*metabolism [MESH] |Signaling Lymphocytic Activation Molecule Family/genetics [MESH] |T-Lymphocytes/*immunology/metabolism [MESH] |Tyrosine/metabolism [MESH]Decreased SAP Expression in T Cells from Patients with Systemic Lupus (epmc).pdf DeepDyve Pubget Overpricing