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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Card+Electrophysiol+Clin 2016 ; 8 (2): 307-22 Nephropedia Template TP
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Cardiac Delayed Rectifier Potassium Channels in Health and Disease #MMPMID27261823
Chen L; Sampson KJ; Kass RS
Card Electrophysiol Clin 2016[Jun]; 8 (2): 307-22 PMID27261823show ga
Cardiac delayed rectifier potassium channels conduct outward potassium currents during the plateau phase of action potentials and play pivotal roles in cardiac repolarization. These include IKs, IKr and the atrial specific IKur channels. In this chapter, we will review the molecular identities and biophysical properties of these channels. Mutations in the genes encoding delayed rectifiers lead to loss- or gain-of-function phenotypes, disrupt normal cardiac repolarization and result in various cardiac rhythm disorders, including congenital Long QT Syndrome, Short QT Syndrome and familial atrial fibrillation. We will also discuss the possibility and prospect of using delayed rectifier channels as therapeutic targets to manage cardiac arrhythmia.