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10.1667/RR14213.1

http://scihub22266oqcxt.onion/10.1667/RR14213.1
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suck abstract from ncbi


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pmid27128740      Radiat+Res 2016 ; 185 (5): 473-84
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  • Thyroid Cancer after Childhood Exposure to External Radiation: An Updated Pooled Analysis of 12 Studies #MMPMID27128740
  • Veiga LHS; Holmberg E; Anderson H; Pottern L; Sadetzki S; Adams MJ; Sakata R; Schneider AB; Inskip P; Bhatti P; Johansson R; Neta G; Shore R; de Vathaire F; Damber L; Kleinerman R; Hawkins MM; Tucker M; Lundell M; Lubin JH
  • Radiat Res 2016[May]; 185 (5): 473-84 PMID27128740show ga
  • Studies have causally linked external thyroid radiation exposure in childhood with thyroid cancer. In 1995, investigators conducted relative risk analyses of pooled data from seven epidemiologic studies. Doses were mostly <10 Gy, although childhood cancer therapies can result in thyroid doses >50 Gy. We pooled data from 12 studies of thyroid cancer patients who were exposed to radiation in childhood (ages <20 years), more than doubling the data, including 1,070 (927 exposed) thyroid cancers and 5.3 million (3.4 million exposed) person-years. Relative risks increased supralinearly through 2?4 Gy, leveled off between 10?30 Gy and declined thereafter, remaining significantly elevated above 50 Gy. There was a significant relative risk trend for doses <0.10 Gy (P < 0.01), with no departure from linearity (P = 0.36). We observed radiogenic effects for both papillary and nonpapillary tumors. Estimates of excess relative risk per Gy (ERR/Gy) were homogeneous by sex (P = 0.35) and number of radiation treatments (P = 0.84) and increased with decreasing age at the time of exposure. The ERR/Gy estimate was significant within ten years of radiation exposure, 2.76 (95% CI, 0.94?4.98), based on 42 exposed cases, and remained elevated 50 years and more after exposure. Finally, exposure to chemotherapy was significantly associated with thyroid cancer, with results supporting a nonsynergistic (additive) association with radiation.
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