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10.1016/j.immuni.2016.04.007 http://scihub22266oqcxt.onion/10.1016/j.immuni.2016.04.007 C4893782!4893782!27178467     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2016 ; 44 (5): 1140-50 Nephropedia Template TP {{tp|p=27178467|t=2016. A progenitor cell expressing transcription factor ROR?t generates all human innate lymphoid cell subsets |pdf=|usr=}}{{27178467}} gab.com Text A progenitor cell expressing transcription factor ROR t generates all human innate lymphoid cell subsets JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=27178467 #FOAvip The current model of murine innate lymphoid cell (ILC) development holds that mouse ILCs are derived downstream of the common lymphoid progenitor through lineage-restricted progenitors. However, corresponding lineage-restricted progenitors in humans have yet to be discovered. Here we identified a progenitor population in human secondary lymphoid tissues (SLTs) that expressed the transcription factor, ROR?t, and was unique in its ability to generate all known ILC subsets, including natural killer (NK) cells, but not other leukocyte populations. In contrast to murine fate-mapping data, which indicate that only ILC3 cells express Ror?t, these human progenitor cells as well as human peripheral blood NK cells and all mature ILC populations expressed ROR?t. Thus, all human ILCs can be generated through an ROR?t+ developmental pathway from a common progenitor in SLTs. These findings help establish the developmental signals and pathways involved in human ILC development. Twit Text FOAVip A progenitor cell expressing transcription factor ROR t generates all human innate lymphoid cell subsets ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=27178467 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27178467 #FOAvip English Wikipedia <ref>{{Cite pmid|27178467}}</ref> A progenitor cell expressing transcription factor ROR?t generates all human innate lymphoid cell subsets #MMPMID27178467 Scoville SD; Mundy-Bosse BL; Zhang MH; Chen L; Zhang X; Keller KA; Hughes T; Chen L; Cheng S; Bergin SM; Mao HC; McClory S; Yu J; Carson WE; Caligiuri MA; Freud AG Immunity 2016[May]; 44 (5): 1140-50 PMID27178467show ga The current model of murine innate lymphoid cell (ILC) development holds that mouse ILCs are derived downstream of the common lymphoid progenitor through lineage-restricted progenitors. However, corresponding lineage-restricted progenitors in humans have yet to be discovered. Here we identified a progenitor population in human secondary lymphoid tissues (SLTs) that expressed the transcription factor, ROR?t, and was unique in its ability to generate all known ILC subsets, including natural killer (NK) cells, but not other leukocyte populations. In contrast to murine fate-mapping data, which indicate that only ILC3 cells express Ror?t, these human progenitor cells as well as human peripheral blood NK cells and all mature ILC populations expressed ROR?t. Thus, all human ILCs can be generated through an ROR?t+ developmental pathway from a common progenitor in SLTs. These findings help establish the developmental signals and pathways involved in human ILC development. äA progenitor cell expressing transcription factor ROR?t generates all (epmc).pdf DeepDyve Pubget Overpricing