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2016 ; 6
(ä): 27209
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miR-21-5p renal expression is associated with fibrosis and renal survival in
patients with IgA nephropathy
#MMPMID27264483
Hennino MF
; Buob D
; Van der Hauwaert C
; Gnemmi V
; Jomaa Z
; Pottier N
; Savary G
; Drumez E
; Noël C
; Cauffiez C
; Glowacki F
Sci Rep
2016[Jun]; 6
(ä): 27209
PMID27264483
show ga
IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis, whose
prognosis is highly variable. Interstitial fibrosis is a strong independent
prognosis factor. Among microRNA involved in renal fibrogenesis, only few have
been investigated in IgAN. In the context of IgAN, we aimed to analyze the role
of miR-21-5p, miR-214-3p and miR-199a-5p, three established "fibromiRs" involved
in renal fibrosis. Fifty-six IgAN biopsy specimens were retrospectively scored
according to Oxford classification. Renal expression of miR-21-5p, miR-214-3p and
miR-199a-5p were significantly associated with T score (miR-21-5p T0 RQ
median?=?1.23, T1 RQ?=?3.01, T2 RQ?=?3.90; miR-214-5p T0 RQ?=?1.39, T1 RQ?=?2.20,
T2 RQ?=?2.48; miR-199a-5p T0 RQ?=?0.76, T1 RQ?=?1.41, T2 RQ?=?1.87). miR-21-5p
expression was associated with S score (S0 RQ median?=?1.31, S1 RQ?=?2.65), but
not miR-214-3p nor miR-199a-5p. In our cohort, poor renal survival was associated
with high blood pressure, proteinuria and elevated creatininemia, as well as T
and S scores. Moreover, renal expression of miR-21-5p, miR-214-3p were associated
with renal survival. In conclusion, miR-21-5p, miR-214-3p and miR-199a-5p are
three "fibromiRs" involved in renal fibrosis in the course of IgAN and miR-21-5p
and miR-214-3p are associated with renal survival.