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10.1038/srep27209

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suck abstract from ncbi


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pmid27264483
      Sci+Rep 2016 ; 6 (ä): 27209
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  • miR-21-5p renal expression is associated with fibrosis and renal survival in patients with IgA nephropathy #MMPMID27264483
  • Hennino MF ; Buob D ; Van der Hauwaert C ; Gnemmi V ; Jomaa Z ; Pottier N ; Savary G ; Drumez E ; Noël C ; Cauffiez C ; Glowacki F
  • Sci Rep 2016[Jun]; 6 (ä): 27209 PMID27264483 show ga
  • IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis, whose prognosis is highly variable. Interstitial fibrosis is a strong independent prognosis factor. Among microRNA involved in renal fibrogenesis, only few have been investigated in IgAN. In the context of IgAN, we aimed to analyze the role of miR-21-5p, miR-214-3p and miR-199a-5p, three established "fibromiRs" involved in renal fibrosis. Fifty-six IgAN biopsy specimens were retrospectively scored according to Oxford classification. Renal expression of miR-21-5p, miR-214-3p and miR-199a-5p were significantly associated with T score (miR-21-5p T0 RQ median?=?1.23, T1 RQ?=?3.01, T2 RQ?=?3.90; miR-214-5p T0 RQ?=?1.39, T1 RQ?=?2.20, T2 RQ?=?2.48; miR-199a-5p T0 RQ?=?0.76, T1 RQ?=?1.41, T2 RQ?=?1.87). miR-21-5p expression was associated with S score (S0 RQ median?=?1.31, S1 RQ?=?2.65), but not miR-214-3p nor miR-199a-5p. In our cohort, poor renal survival was associated with high blood pressure, proteinuria and elevated creatininemia, as well as T and S scores. Moreover, renal expression of miR-21-5p, miR-214-3p were associated with renal survival. In conclusion, miR-21-5p, miR-214-3p and miR-199a-5p are three "fibromiRs" involved in renal fibrosis in the course of IgAN and miR-21-5p and miR-214-3p are associated with renal survival.
  • |Adult [MESH]
  • |Female [MESH]
  • |Fibrosis [MESH]
  • |Glomerulonephritis, IGA/*genetics/*pathology [MESH]
  • |Humans [MESH]
  • |Kidney/*pathology [MESH]
  • |Male [MESH]
  • |MicroRNAs/*genetics [MESH]
  • |Middle Aged [MESH]
  • |Risk Factors [MESH]
  • |Up-Regulation [MESH]


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