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10.1038/srep27250 http://scihub22266oqcxt.onion/10.1038/srep27250 C4893707!4893707 !27264273     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27264273 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 27250 Nephropedia Template TP {{tp|p=27264273 |t=2016. Synchrotron X-ray microtransections: a non invasive approach for epileptic seizures arising from eloquent cortical areas |pdf=|usr=}}{{27264273 }} gab.com Text Synchrotron X-ray microtransections: a non invasive approach for epileptic seizures arising from eloquent cortical areas JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27264273 #FOAvip Synchrotron-generated X-ray (SRX) microbeams deposit high radiation doses to submillimetric targets whilst minimizing irradiation of neighboring healthy tissue. We developed a new radiosurgical method which demonstrably transects cortical brain tissue without affecting adjacent regions. We made such image-guided SRX microtransections in the left somatosensory cortex in a rat model of generalized epilepsy using high radiation doses (820?Gy) in thin (200??m) parallel slices of tissue. This procedure, targeting the brain volume from which seizures arose, altered the abnormal neuronal activities for at least 9 weeks, as evidenced by a decrease of seizure power and coherence between tissue slices in comparison to the contralateral cortex. The brain tissue located between transections stayed histologically normal, while the irradiated micro-slices remained devoid of myelin and neurons two months after irradiation. This pre-clinical proof of concept highlights the translational potential of non-invasive SRX transections for treating epilepsies that are not eligible for resective surgery. Twit Text FOAVip Synchrotron X-ray microtransections: a non invasive approach for epileptic seizures arising from eloquent cortical areas ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27264273 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27264273 #FOAvip English Wikipedia <ref>{{Cite pmid|27264273 }}</ref> Synchrotron X-ray microtransections: a non invasive approach for epileptic seizures arising from eloquent cortical areas #MMPMID27264273 Pouyatos B ; Nemoz C ; Chabrol T ; Potez M ; Bräuer E ; Renaud L ; Pernet-Gallay K ; Estève F ; David O ; Kahane P ; Laissue JA ; Depaulis A ; Serduc R Sci Rep 2016[Jun]; 6 (ä): 27250 PMID27264273 show ga Synchrotron-generated X-ray (SRX) microbeams deposit high radiation doses to submillimetric targets whilst minimizing irradiation of neighboring healthy tissue. We developed a new radiosurgical method which demonstrably transects cortical brain tissue without affecting adjacent regions. We made such image-guided SRX microtransections in the left somatosensory cortex in a rat model of generalized epilepsy using high radiation doses (820?Gy) in thin (200??m) parallel slices of tissue. This procedure, targeting the brain volume from which seizures arose, altered the abnormal neuronal activities for at least 9 weeks, as evidenced by a decrease of seizure power and coherence between tissue slices in comparison to the contralateral cortex. The brain tissue located between transections stayed histologically normal, while the irradiated micro-slices remained devoid of myelin and neurons two months after irradiation. This pre-clinical proof of concept highlights the translational potential of non-invasive SRX transections for treating epilepsies that are not eligible for resective surgery. |Animals [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Radiosurgery/*instrumentation [MESH] |Rats [MESH] |Seizures/physiopathology/*radiotherapy [MESH] |Somatosensory Cortex/physiopathology/*radiation effects [MESH]Synchrotron X-ray microtransections: a non invasive approach for epile(epmc).pdf DeepDyve Pubget Overpricing