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2016 ; 5
(3
): 280-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Peyronie s disease: a literature review on epidemiology, genetics,
pathophysiology, diagnosis and work-up
#MMPMID27298774
Al-Thakafi S
; Al-Hathal N
Transl Androl Urol
2016[Jun]; 5
(3
): 280-9
PMID27298774
show ga
Peyronie's disease (PD), a fibromatous disorder of the tunica albuginea of the
penile corpus cavernosum, named after the French physician Francois de la
Peyronie, is characterized by pain, plaque formation, penile curvature, and
plaque calcification. The epidemiological data on PD is inconsistent, with recent
reports stating a prevalence of up to 9%, and the condition affecting men of all
ages, from teenagers to septuagenarians. We are just beginning to elucidate the
role of genetics as a causative factor for PD. Chromosomal abnormalities and
single-nucleotide polymorphisms have been shown to be associated with fibrotic
diatheses. Tunical mechanical stress and microvascular trauma are major
contributory factors to the pathophysiology of PD. The diagnosis of PD can be
made using a combination of clinical history, physical examination and,
sometimes, imaging modalities. A better understanding of the molecular
pathophysiology of this condition remains paramount for the development of newer
and more effective disease-targeted interventions.