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10.3748/wjg.v22.i22.5285 http://scihub22266oqcxt.onion/10.3748/wjg.v22.i22.5285 C4893476!4893476 !27298572     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27298572 &cmd=llinks): Failed to open stream: HTTP request failed! 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Hepatitis C virus genotype 3: Meta-analysis on sustained virologic response rates with currently available treatment options |pdf=|usr=}}{{27298572 }} gab.com Text Hepatitis C virus genotype 3: Meta-analysis on sustained virologic response rates with currently available treatment options JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=27298572 #FOAvip AIM: To address the therapeutic efficacy of various treatment regimens in genotype 3 selecting randomized clinical trials and prospective National Cohort Studies. METHODS: (1) PEG-INF-based therapy including sofosbuvir (SOF) + RBV for 12 wk vs SOF + RBV 24 wk; (2) SOF + RBV therapy 12 wk/16 wk vs 24 wk; and (3) the role of RBV in SOF + daclatasvir (DCV) and SOF + ledipasvir (LDV) combinations. This meta-analysis provides robust information with the intention of addressing treatment strategy for hepatitis C virus genotype 3. RESULTS: A combination treatment including SOF + RBV + PEG-IFN for 12 wk notes better SVR than with only SOF + RBV for 12 wk, although its association with more frequent adverse effects may be a limiting factor. Longer duration therapy with SOF + RBV (24 wk) has achieved higher SVR rates than shorter durations (12 or 16 wk). SOF + LDV are not an ideal treatment for genotype 3. CONCLUSION: Lastly, SOF + DCV combination is probably the best oral therapy option and the addition of RBV does not appear to be needed to increase SVR rates substantially. Twit Text FOAVip Hepatitis C virus genotype 3: Meta-analysis on sustained virologic response rates with currently available treatment options ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=27298572 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27298572 #FOAvip English Wikipedia <ref>{{Cite pmid|27298572 }}</ref> Hepatitis C virus genotype 3: Meta-analysis on sustained virologic response rates with currently available treatment options #MMPMID27298572 Ampuero J ; Reddy KR ; Romero-Gomez M World J Gastroenterol 2016[Jun]; 22 (22 ): 5285-92 PMID27298572 show ga AIM: To address the therapeutic efficacy of various treatment regimens in genotype 3 selecting randomized clinical trials and prospective National Cohort Studies. METHODS: (1) PEG-INF-based therapy including sofosbuvir (SOF) + RBV for 12 wk vs SOF + RBV 24 wk; (2) SOF + RBV therapy 12 wk/16 wk vs 24 wk; and (3) the role of RBV in SOF + daclatasvir (DCV) and SOF + ledipasvir (LDV) combinations. This meta-analysis provides robust information with the intention of addressing treatment strategy for hepatitis C virus genotype 3. RESULTS: A combination treatment including SOF + RBV + PEG-IFN for 12 wk notes better SVR than with only SOF + RBV for 12 wk, although its association with more frequent adverse effects may be a limiting factor. Longer duration therapy with SOF + RBV (24 wk) has achieved higher SVR rates than shorter durations (12 or 16 wk). SOF + LDV are not an ideal treatment for genotype 3. CONCLUSION: Lastly, SOF + DCV combination is probably the best oral therapy option and the addition of RBV does not appear to be needed to increase SVR rates substantially. |Administration, Oral [MESH] |Antiviral Agents/administration & dosage/adverse effects/*therapeutic use [MESH] |Carbamates [MESH] |Drug Resistance, Viral/genetics [MESH] |Drug Therapy, Combination [MESH] |Genotype [MESH] |Hepacivirus/*drug effects/*genetics/pathogenicity [MESH] |Hepatitis C/diagnosis/*drug therapy/virology [MESH] |Humans [MESH] |Imidazoles/therapeutic use [MESH] |Odds Ratio [MESH] |Prospective Studies [MESH] |Pyrrolidines [MESH] |Randomized Controlled Trials as Topic [MESH] |Ribavirin/therapeutic use [MESH] |Sofosbuvir/therapeutic use [MESH] |Sustained Virologic Response [MESH] |Time Factors [MESH]Hepatitis C virus genotype 3: Meta-analysis on sustained virologic res(epmc).pdf DeepDyve Pubget Overpricing