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2016 ; 22
(22
): 5211-27
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Visceral hypersensitive rats share common dysbiosis features with irritable bowel
syndrome patients
#MMPMID27298564
Zhou XY
; Li M
; Li X
; Long X
; Zuo XL
; Hou XH
; Cong YZ
; Li YQ
World J Gastroenterol
2016[Jun]; 22
(22
): 5211-27
PMID27298564
show ga
AIM: To evaluate gut microbial dysbiosis in two visceral hypersensitive models in
comparison with irritable bowel syndrome (IBS) patients and to explore the extent
to which these models capture the dysbiosis of IBS patients. METHODS: Visceral
hypersensitivity was developed using the maternal separation (MS) rat model and
post-inflammatory rat model. The visceral sensitivity of the model groups and
control group was evaluated using the abdominal withdraw reflex score and
electromyography in response to graded colorectal distention. The 16S ribosomal
RNA gene from fecal samples was pyrosequenced and analyzed. The correlation
between dysbiosis in the microbiota and visceral hypersensitivity was calculated.
Positive findings were compared to sequencing data from a published human IBS
cohort. RESULTS: Dysbiosis triggered by neonatal maternal separation was lasting
but not static. Both MS and post-inflammatory rat fecal microbiota deviated from
that of the control rats to an extent that was larger than the co-housing effect.
Two short chain fatty acid producing genera, Fusobacterium and Clostridium XI,
were shared by the human IBS cohort and by the maternal separation rats and
post-inflammatory rats, respectively, to different extents. Fusobacterium was
significantly increased in the MS group, and its abundance positively correlated
with the degree of visceral hypersensitivity. Porphyromonadaceae was a protective
biomarker for both the rat control group and healthy human controls. CONCLUSION:
The dysbiosis MS rat model and the post-inflammatory rat model captured some of
the dysbiosis features of IBS patients. Fusobacterium, Clostridium XI and
Porphyromonadaceae were identified as targets for future mechanistic research.
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