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10.1186/s13054-016-1350-1 http://scihub22266oqcxt.onion/10.1186/s13054-016-1350-1 C4893417!4893417!27262736     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Crit+Care 2016 ; 20 (ä): ä Nephropedia Template TP {{tp|p=27262736|t=2016. Structural equation modelling exploration of the key pathophysiological processes involved in cardiac surgery-related acute kidney injury in infants |pdf=|usr=}}{{27262736}} gab.com Text Structural equation modelling exploration of the key pathophysiological processes involved in cardiac surgery-related acute kidney injury in infants JO: Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=27262736 #FOAvip Background: Uncertainties about the pathophysiological processes resulting in cardiac surgery-related acute kidney injury (AKI) in infants concern the relative impact of the most prominent risk factors, the clinical relevance of changes in glomerular filtration rate vs tubular injury, and the usefulness of available diagnostic tools. Structural equation modelling could allow for the assessment of these complex relationships. Methods: A structural model was specified using data from a prospective observational cohort of 200 patients <1 year of age undergoing cardiopulmonary bypass surgery. It included four latent variables: AKI, modelled as a construct of perioperative creatinine variation, of oliguria and of urine neutrophil gelatinase-associated lipocalin (uNGAL) concentrations; the cardiopulmonary bypass characteristics; the occurrence of a post-operative low cardiac output syndrome and the post-operative outcome. Results: The model showed a good fit, and all path coefficients were statistically significant. The bypass was the most prominent risk factor, with a path coefficient of 0.820 (95 % CI 0.527?0.979), translating to a 67.2 % explanation for the risk of AKI. A strong relationships was found between AKI and early uNGAL excretion, and between AKI and the post-operative outcome, with path coefficients of 0.611 (95 % CI 0.347?0.777) and 0.741 (95 % CI 0.610?0.988), respectively. The path coefficient between AKI and a >50 % increase in serum creatinine was smaller, with a path coefficient of 0.443 (95 % CI 0.273?0.596), and was intermediate for oliguria, defined as urine output <0.5 ml kg?1 h?1, with a path coefficient of 0.495 (95 % CI 0.250?0.864). A path coefficient of ?0.229 (95 % CI ?0.319 to 0.060) suggested that the risk of AKI during the first year of life did not increase with younger age at surgery. Conclusions: These findings suggest that cardiac surgery-related AKI in infants is a translation of tubular injury, predominately driven by the cardiopulmonary bypass, and linked to early uNGAL excretion and to post-operative outcome. Trial registration: ClinicalTrials.gov identifier NCT01219998. Registered 11 October 2010. Electronic supplementary material: The online version of this article (doi:10.1186/s13054-016-1350-1) contains supplementary material, which is available to authorized users. Twit Text FOAVip Structural equation modelling exploration of the key pathophysiological processes involved in cardiac surgery-related acute kidney injury in infants ????Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=27262736 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27262736 #FOAvip English Wikipedia <ref>{{Cite pmid|27262736}}</ref> Structural equation modelling exploration of the key pathophysiological processes involved in cardiac surgery-related acute kidney injury in infants #MMPMID27262736 Bojan M; Basto Duarte MC; Ermak N; Lopez-Lopez V; Mogenet A; Froissart M Crit Care 2016[]; 20 (ä): ä PMID27262736show ga Background: Uncertainties about the pathophysiological processes resulting in cardiac surgery-related acute kidney injury (AKI) in infants concern the relative impact of the most prominent risk factors, the clinical relevance of changes in glomerular filtration rate vs tubular injury, and the usefulness of available diagnostic tools. Structural equation modelling could allow for the assessment of these complex relationships. Methods: A structural model was specified using data from a prospective observational cohort of 200 patients <1 year of age undergoing cardiopulmonary bypass surgery. It included four latent variables: AKI, modelled as a construct of perioperative creatinine variation, of oliguria and of urine neutrophil gelatinase-associated lipocalin (uNGAL) concentrations; the cardiopulmonary bypass characteristics; the occurrence of a post-operative low cardiac output syndrome and the post-operative outcome. Results: The model showed a good fit, and all path coefficients were statistically significant. The bypass was the most prominent risk factor, with a path coefficient of 0.820 (95 % CI 0.527?0.979), translating to a 67.2 % explanation for the risk of AKI. A strong relationships was found between AKI and early uNGAL excretion, and between AKI and the post-operative outcome, with path coefficients of 0.611 (95 % CI 0.347?0.777) and 0.741 (95 % CI 0.610?0.988), respectively. The path coefficient between AKI and a >50 % increase in serum creatinine was smaller, with a path coefficient of 0.443 (95 % CI 0.273?0.596), and was intermediate for oliguria, defined as urine output <0.5 ml kg?1 h?1, with a path coefficient of 0.495 (95 % CI 0.250?0.864). A path coefficient of ?0.229 (95 % CI ?0.319 to 0.060) suggested that the risk of AKI during the first year of life did not increase with younger age at surgery. Conclusions: These findings suggest that cardiac surgery-related AKI in infants is a translation of tubular injury, predominately driven by the cardiopulmonary bypass, and linked to early uNGAL excretion and to post-operative outcome. Trial registration: ClinicalTrials.gov identifier NCT01219998. Registered 11 October 2010. Electronic supplementary material: The online version of this article (doi:10.1186/s13054-016-1350-1) contains supplementary material, which is available to authorized users. äStructural equation modelling exploration of the key pathophysiologica(epmc).pdf DeepDyve Pubget Overpricing