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10.1136/thoraxjnl-2015-208215 http://scihub22266oqcxt.onion/10.1136/thoraxjnl-2015-208215 C4893128!4893128 !26911575     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26911575 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Thorax 2016 ; 71 (6 ): 565-7 Nephropedia Template TP {{tp|p=26911575 |t=2016. Caffeine inhibits TGF? activation in epithelial cells, interrupts fibroblast responses to TGF?, and reduces established fibrosis in ex vivo precision-cut lung slices |pdf=|usr=}}{{26911575 }} gab.com Text Caffeine inhibits TGF activation in epithelial cells, interrupts fibroblast responses to TGF , and reduces established fibrosis in ex vivo precision-cut lung slices JO: Thorax http://www.kidney.de/pget.php?&tw=1&pmid=26911575 #FOAvip Caffeine is a commonly used food additive found naturally in many products. In addition to potently stimulating the central nervous system caffeine is able to affect various systems within the body including the cardiovascular and respiratory systems. Importantly, caffeine is used clinically to treat apnoea and bronchopulmonary dysplasia in premature babies. Recently, caffeine has been shown to exhibit antifibrotic effects in the liver in part through reducing collagen expression and deposition, and reducing expression of the profibrotic cytokine TGF?. The potential antifibrotic effects of caffeine in the lung have not previously been investigated. Using a combined in vitro and ex vivo approach we have demonstrated that caffeine can act as an antifibrotic agent in the lung by acting on two distinct cell types, namely epithelial cells and fibroblasts. Caffeine inhibited TGF? activation by lung epithelial cells in a concentration-dependent manner but had no effect on TGF? activation in fibroblasts. Importantly, however, caffeine abrogated profibrotic responses to TGF? in lung fibroblasts. It inhibited basal expression of the ?-smooth muscle actin gene and reduced TGF?-induced increases in profibrotic genes. Finally, caffeine reduced established bleomycin-induced fibrosis after 5?days treatment in an ex vivo precision-cut lung slice model. Together, these findings suggest that there is merit in further investigating the potential use of caffeine, or its analogues, as antifibrotic agents in the lung. Twit Text FOAVip Caffeine inhibits TGF activation in epithelial cells, interrupts fibroblast responses to TGF , and reduces established fibrosis in ex vivo precision-cut lung slices ????Thorax http://www.kidney.de/pget.php?&tw=1&pmid=26911575 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26911575 #FOAvip English Wikipedia <ref>{{Cite pmid|26911575 }}</ref> Caffeine inhibits TGF? activation in epithelial cells, interrupts fibroblast responses to TGF?, and reduces established fibrosis in ex vivo precision-cut lung slices #MMPMID26911575 Tatler AL ; Barnes J ; Habgood A ; Goodwin A ; McAnulty RJ ; Jenkins G Thorax 2016[Jun]; 71 (6 ): 565-7 PMID26911575 show ga Caffeine is a commonly used food additive found naturally in many products. In addition to potently stimulating the central nervous system caffeine is able to affect various systems within the body including the cardiovascular and respiratory systems. Importantly, caffeine is used clinically to treat apnoea and bronchopulmonary dysplasia in premature babies. Recently, caffeine has been shown to exhibit antifibrotic effects in the liver in part through reducing collagen expression and deposition, and reducing expression of the profibrotic cytokine TGF?. The potential antifibrotic effects of caffeine in the lung have not previously been investigated. Using a combined in vitro and ex vivo approach we have demonstrated that caffeine can act as an antifibrotic agent in the lung by acting on two distinct cell types, namely epithelial cells and fibroblasts. Caffeine inhibited TGF? activation by lung epithelial cells in a concentration-dependent manner but had no effect on TGF? activation in fibroblasts. Importantly, however, caffeine abrogated profibrotic responses to TGF? in lung fibroblasts. It inhibited basal expression of the ?-smooth muscle actin gene and reduced TGF?-induced increases in profibrotic genes. Finally, caffeine reduced established bleomycin-induced fibrosis after 5?days treatment in an ex vivo precision-cut lung slice model. Together, these findings suggest that there is merit in further investigating the potential use of caffeine, or its analogues, as antifibrotic agents in the lung. |Animals [MESH] |Biomarkers/metabolism [MESH] |Caffeine/*pharmacology [MESH] |Cells, Cultured [MESH] |Epithelial Cells/*drug effects/metabolism [MESH] |Fibroblasts/*drug effects/metabolism [MESH] |Gene Expression Regulation/drug effects [MESH] |Humans [MESH] |Mice [MESH] |Pulmonary Fibrosis/*drug therapy/genetics/*metabolism [MESH] |Signal Transduction/drug effects [MESH]Caffeine inhibits TGF? activation in epithelial cells, interrupts fibr(epmc).pdf DeepDyve Pubget Overpricing