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PRINS, a primate-specific long non-coding RNA, plays a role in the keratinocyte
stress response and psoriasis pathogenesis
#MMPMID26935426
Széll M
; Danis J
; Bata-Csörg? Z
; Kemény L
Pflugers Arch
2016[Jun]; 468
(6
): 935-43
PMID26935426
show ga
In the last few years with the recent emergence of high-throughput technologies,
thousands of long non-coding RNAs (lncRNAs) have been identified in the human
genome. However, assigning functional annotation and determining cellular
contexts for these RNAs are still in its infancy. As information gained about
lncRNA structure, interacting partners, and roles in human diseases may be
helpful in the characterization of novel lncRNAs, we review our knowledge on a
selected group of lncRNAs that were identified serendipitously years ago by
large-scale gene expression methods used to study human diseases. In particular,
we focus on the Psoriasis-susceptibility-Related RNA Gene Induced by Stress
(PRINS) lncRNA, first identified by our research group as a transcript highest
expressed in psoriatic non-lesional epidermis. Results gathered for PRINS in the
last 10 years indicate that it is conserved in primates and plays a role in
keratinocyte stress response. Elevated levels of PRINS expression in psoriatic
non-lesional keratinocytes alter the stress response of non-lesional epidermis
and contribute to disease pathogenesis. Finally, we propose a categorization for
the PRINS lncRNA based on a recently elaborated system for lncRNA classification.
|Animals
[MESH]
|Humans
[MESH]
|Keratinocytes/*metabolism/pathology
[MESH]
|Primates
[MESH]
|Psoriasis/*etiology/genetics/metabolism
[MESH]
|RNA, Long Noncoding/classification/*genetics
[MESH]
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