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10.1038/onc.2013.37 http://scihub22266oqcxt.onion/10.1038/onc.2013.37 C4893026!4893026!23435428     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogene 2014 ; 33 (7): 933-8 Nephropedia Template TP {{tp|p=23435428|t=2014. Activation of ?-catenin/TCF targets following loss of the tumor suppressor SNF5 |pdf=|usr=}}{{23435428}} gab.com Text Activation of -catenin/TCF targets following loss of the tumor suppressor SNF5 JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=23435428 #FOAvip The SWI/SNF chromatin remodeling complex is a master regulator of developmental cell fate decisions, although the key target pathways are poorly characterized. Here, we interrogated the contribution of the SWI/SNF subunit and tumor suppressor SNF5 to the regulation of developmental pathways using conditional mouse and cell culture models. We find that loss of Snf5 phenocopies ?-catenin hyperactivation and that SNF5 is essential for regulating Wnt/?-catenin pathway target expression. These data provide insight into chromatin-based mechanisms that underlie developmental regulation and elucidate the emerging theme that mutation of this tumor suppressor complex can activate developmental pathways by uncoupling them from upstream control. Twit Text FOAVip Activation of -catenin/TCF targets following loss of the tumor suppressor SNF5 ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=23435428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23435428 #FOAvip English Wikipedia <ref>{{Cite pmid|23435428}}</ref> Activation of ?-catenin/TCF targets following loss of the tumor suppressor SNF5 #MMPMID23435428 Mora-Blanco EL; Mishina Y; Tillman EJ; Cho YJ; Thom CS; Pomeroy SL; Shao W; Roberts CW Oncogene 2014[Feb]; 33 (7): 933-8 PMID23435428show ga The SWI/SNF chromatin remodeling complex is a master regulator of developmental cell fate decisions, although the key target pathways are poorly characterized. Here, we interrogated the contribution of the SWI/SNF subunit and tumor suppressor SNF5 to the regulation of developmental pathways using conditional mouse and cell culture models. We find that loss of Snf5 phenocopies ?-catenin hyperactivation and that SNF5 is essential for regulating Wnt/?-catenin pathway target expression. These data provide insight into chromatin-based mechanisms that underlie developmental regulation and elucidate the emerging theme that mutation of this tumor suppressor complex can activate developmental pathways by uncoupling them from upstream control. äActivation of ?-catenin/TCF targets following loss of the tumor suppre(epmc).pdf DeepDyve Pubget Overpricing