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10.1002/sim.6886 http://scihub22266oqcxt.onion/10.1002/sim.6886 C4892992!4892992!26833922     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stat+Med 2016 ; 35 (15): 2516-24 Nephropedia Template TP {{tp|p=26833922|t=2016. THE RAPID ENROLLMENT DESIGN FOR PHASE I CLINICAL TRIALS |pdf=|usr=}}{{26833922}} gab.com Text THE RAPID ENROLLMENT DESIGN FOR PHASE I CLINICAL TRIALS JO: Stat Med http://www.kidney.de/pget.php?&tw=1&pmid=26833922 #FOAvip We propose a dose-finding design for Phase I oncology trials where each new patient is assigned to the dose most likely to be the target dose given observed data. The main model assumption is that the dose-toxicity curve is non-decreasing. This method is beneficial when it is desirable to assign a patient to a dose as soon as the patient is enrolled into a study. To prevent assignments to doses with limited toxicity information in fast accruing trials we propose a conservative rule that assigns temporary fractional toxicities to patients still in follow-up. We also recommend using a safety rule with any dose-finding method. Twit Text FOAVip THE RAPID ENROLLMENT DESIGN FOR PHASE I CLINICAL TRIALS ????Stat Med http://www.kidney.de/pget.php?&tw=1&pmid=26833922 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26833922 #FOAvip English Wikipedia <ref>{{Cite pmid|26833922}}</ref> THE RAPID ENROLLMENT DESIGN FOR PHASE I CLINICAL TRIALS #MMPMID26833922 Ivanova A; Wang Y; Foster MC Stat Med 2016[Jul]; 35 (15): 2516-24 PMID26833922show ga We propose a dose-finding design for Phase I oncology trials where each new patient is assigned to the dose most likely to be the target dose given observed data. The main model assumption is that the dose-toxicity curve is non-decreasing. This method is beneficial when it is desirable to assign a patient to a dose as soon as the patient is enrolled into a study. To prevent assignments to doses with limited toxicity information in fast accruing trials we propose a conservative rule that assigns temporary fractional toxicities to patients still in follow-up. We also recommend using a safety rule with any dose-finding method. äTHE RAPID ENROLLMENT DESIGN FOR PHASE I CLINICAL TRIALS (epmc).pdf DeepDyve Pubget Overpricing