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10.1016/j.semcdb.2015.11.013

http://scihub22266oqcxt.onion/10.1016/j.semcdb.2015.11.013
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C4892986!4892986!26658098
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suck abstract from ncbi


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pmid26658098      Semin+Cell+Dev+Biol 2016 ; 57 (ä): 24-30
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  • Towards a predictive model of chromatin 3D organization #MMPMID26658098
  • Xu C; Corces VG
  • Semin Cell Dev Biol 2016[Sep]; 57 (ä): 24-30 PMID26658098show ga
  • Architectural proteins mediate interactions between distant regions in the genome to bring together different regulatory elements while establishing a specific three-dimensional organization of the genetic material. Depletion of specific architectural proteins leads to miss regulation of gene expression and alterations in nuclear organization. The specificity of interactions mediated by architectural proteins depends on the nature, number, and orientation of their binding site at individual genomic locations. Knowledge of the mechanisms and rules governing interactions among architectural proteins may provide a code to predict the 3D organization of the genome.
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