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10.1038/gene.2016.16 http://scihub22266oqcxt.onion/10.1038/gene.2016.16 C4892947!4892947!27029527     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+Immun 2016 ; 17 (4): 228-38 Nephropedia Template TP {{tp|p=27029527|t=2016. The autoimmunity-associated gene RGS1 affects the frequency of T follicular helper cells |pdf=|usr=}}{{27029527}} gab.com Text The autoimmunity-associated gene RGS1 affects the frequency of T follicular helper cells JO: Genes Immun http://www.kidney.de/pget.php?&tw=1&pmid=27029527 #FOAvip RGS1 (regulator of G-protein signaling 1) has been associated with multiple autoimmune disorders including type 1 diabetes. RGS1 desensitizes the chemokine receptors CCR7 and CXCR4 that are critical to the localization of T and B cells in lymphoid organs. To explore how RGS1 variation contributes to autoimmunity, we generated Rgs1 knockdown (KD) mice in the nonobese diabetic (NOD) model for type 1 diabetes. We found that Rgs1 KD increased the size of germinal centers, but decreased the frequency of T follicular helper (TFH) cells. We show that loss of Rgs1 in T cells had both a T cell-intrinsic effect on migration and TFH cell frequency, and an indirect effect on B cell migration and germinal center formation. Notably, several recent publications described an increase in circulating TFH cells in patients with type 1 diabetes, suggesting this cell population is involved in pathogenesis. Though Rgs1 KD was insufficient to alter diabetes frequency in the NOD model, our findings raise the possibility that RGS1 plays a role in autoimmunity owing to its function in TFH cells. This mechanistic link, while speculative at this time, would lend support to the notion that TFH cells are key participants in autoimmunity and could explain RGS1?s association with several immune-mediated diseases. Twit Text FOAVip The autoimmunity-associated gene RGS1 affects the frequency of T follicular helper cells ????Genes Immun http://www.kidney.de/pget.php?&tw=1&pmid=27029527 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27029527 #FOAvip English Wikipedia <ref>{{Cite pmid|27029527}}</ref> The autoimmunity-associated gene RGS1 affects the frequency of T follicular helper cells #MMPMID27029527 Caballero-Franco C; Kissler S Genes Immun 2016[Jun]; 17 (4): 228-38 PMID27029527show ga RGS1 (regulator of G-protein signaling 1) has been associated with multiple autoimmune disorders including type 1 diabetes. RGS1 desensitizes the chemokine receptors CCR7 and CXCR4 that are critical to the localization of T and B cells in lymphoid organs. To explore how RGS1 variation contributes to autoimmunity, we generated Rgs1 knockdown (KD) mice in the nonobese diabetic (NOD) model for type 1 diabetes. We found that Rgs1 KD increased the size of germinal centers, but decreased the frequency of T follicular helper (TFH) cells. We show that loss of Rgs1 in T cells had both a T cell-intrinsic effect on migration and TFH cell frequency, and an indirect effect on B cell migration and germinal center formation. Notably, several recent publications described an increase in circulating TFH cells in patients with type 1 diabetes, suggesting this cell population is involved in pathogenesis. Though Rgs1 KD was insufficient to alter diabetes frequency in the NOD model, our findings raise the possibility that RGS1 plays a role in autoimmunity owing to its function in TFH cells. This mechanistic link, while speculative at this time, would lend support to the notion that TFH cells are key participants in autoimmunity and could explain RGS1?s association with several immune-mediated diseases. äThe autoimmunity-associated gene RGS1 affects the frequency of T folli(epmc).pdf DeepDyve Pubget Overpricing