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10.1093/brain/aww084

http://scihub22266oqcxt.onion/10.1093/brain/aww084
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C4892757!4892757!27190026
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suck abstract from ncbi


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pmid27190026      Brain 2016 ; 139 (6): 1747-61
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  • MicroRNAs targeting TGF? signalling underlie the regulatory T cell defect in multiple sclerosis #MMPMID27190026
  • Severin ME; Lee PW; Liu Y; Selhorst AJ; Gormley MG; Pei W; Yang Y; Guerau-de-Arellano M; Racke MK; Lovett-Racke AE
  • Brain 2016[Jun]; 139 (6): 1747-61 PMID27190026show ga
  • Regulatory T cells (Tregs) are defective in multiple sclerosis. Severin et al. show that TGF? signalling is reduced in T cells in multiple sclerosis owing to overexpression of miRNAs that negatively regulate the TGF? pathway. This results in impaired Treg development, and implicates overexpression of specific miRNAs in multiple sclerosis susceptibility.
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