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Elevated IL-17 and TGF-? Serum Levels: A Positive Correlation between T-helper 17
Cell-Related Pro-Inflammatory Responses with Major Depressive Disorder
#MMPMID27303608
Davami MH
; Baharlou R
; Ahmadi Vasmehjani A
; Ghanizadeh A
; Keshtkar M
; Dezhkam I
; Atashzar MR
Basic Clin Neurosci
2016[Apr]; 7
(2
): 137-42
PMID27303608
show ga
INTRODUCTION: Depression is a mental disorder that highly associated with immune
system. Therefore, this study compares the serum concentrations of IL-21, IL-17,
and transforming growth factor ? (TGF-?) between patients with major depressive
disorder and healthy controls. METHODS: Blood samples were collected from 41
patients with major depressive disorder and 40 healthy age-matched controls with
no history of malignancies or autoimmune disorders. The subjects were interviewed
face to face according to DSM-IV diagnostic criteria. Depression score was
measured using completed Beck Depression Inventory in both groups. The serum
concentrations of IL-21, IL-17, and TGF-? were assessed using ELISA. RESULTS: The
mean score of Beck Depression score in the patient and control groups was
35.4±5.5 and 11.1±2.3. IL-17 serum concentrations in the patients and the control
group were 10.03±0.6 and 7.6±0.6 pg/mL, respectively (P=0.0002). TGF-? level in
the patients group was significantly higher than compare to the control group;
336.7±20.19 vs. 174.8±27.20 pg/mL, (P<0.0001). However, the level of IL-21 was
not statistically different between the two groups 84.30±4.57 vs. 84.12±4.15
pg/mL (P>0.05). CONCLUSION: Considering pro-inflammatory cytokines, current
results support the association of inflammatory response and depressive disorder.
So, it seems that pro-inflammatory factors profile can be used as indicator in
following of depression progress and its treatment impacts.
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