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10.1098/rsif.2015.1106 http://scihub22266oqcxt.onion/10.1098/rsif.2015.1106 C4892257!4892257 !27170649     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27170649 &cmd=llinks): Failed to open stream: HTTP request failed! 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Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype |pdf=|usr=}}{{27170649 }} gab.com Text Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype JO: J R Soc Interface http://www.kidney.de/pget.php?&tw=1&pmid=27170649 #FOAvip Metastasis can involve repeated cycles of epithelial-to-mesenchymal transition (EMT) and its reverse mesenchymal-to-epithelial transition. Cells can also undergo partial transitions to attain a hybrid epithelial/mesenchymal (E/M) phenotype that allows the migration of adhering cells to form a cluster of circulating tumour cells. These clusters can be apoptosis-resistant and possess an increased metastatic propensity as compared to the cells that undergo a complete EMT (mesenchymal cells). Hence, identifying the key players that can regulate the formation and maintenance of such clusters may inform anti-metastasis strategies. Here, we devise a mechanism-based theoretical model that links cell-cell communication via Notch-Delta-Jagged signalling with the regulation of EMT. We demonstrate that while both Notch-Delta and Notch-Jagged signalling can induce EMT in a population of cells, only Jagged-dominated Notch signalling, but not Delta-dominated signalling, can lead to the formation of clusters containing hybrid E/M cells. Our results offer possible mechanistic insights into the role of Jagged in tumour progression, and offer a framework to investigate the effects of other microenvironmental signals during metastasis. Twit Text FOAVip Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype ????J R Soc Interface http://www.kidney.de/pget.php?&tw=1&pmid=27170649 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27170649 #FOAvip English Wikipedia <ref>{{Cite pmid|27170649 }}</ref> Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype #MMPMID27170649 Boareto M ; Jolly MK ; Goldman A ; Pietilä M ; Mani SA ; Sengupta S ; Ben-Jacob E ; Levine H ; Onuchic JN J R Soc Interface 2016[May]; 13 (118 ): ä PMID27170649 show ga Metastasis can involve repeated cycles of epithelial-to-mesenchymal transition (EMT) and its reverse mesenchymal-to-epithelial transition. Cells can also undergo partial transitions to attain a hybrid epithelial/mesenchymal (E/M) phenotype that allows the migration of adhering cells to form a cluster of circulating tumour cells. These clusters can be apoptosis-resistant and possess an increased metastatic propensity as compared to the cells that undergo a complete EMT (mesenchymal cells). Hence, identifying the key players that can regulate the formation and maintenance of such clusters may inform anti-metastasis strategies. Here, we devise a mechanism-based theoretical model that links cell-cell communication via Notch-Delta-Jagged signalling with the regulation of EMT. We demonstrate that while both Notch-Delta and Notch-Jagged signalling can induce EMT in a population of cells, only Jagged-dominated Notch signalling, but not Delta-dominated signalling, can lead to the formation of clusters containing hybrid E/M cells. Our results offer possible mechanistic insights into the role of Jagged in tumour progression, and offer a framework to investigate the effects of other microenvironmental signals during metastasis. |*Epithelial-Mesenchymal Transition [MESH] |*Models, Biological [MESH] |*Signal Transduction [MESH] |Cell Line, Tumor [MESH] |Humans [MESH] |Jagged-1 Protein/*metabolism [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Proteins/*metabolism [MESH] |Neoplasms/*metabolism/pathology [MESH]Notch-Jagged signalling can give rise to clusters of cells exhibiting (epmc).pdf DeepDyve Pubget Overpricing