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10.1039/c1lc20758j

http://scihub22266oqcxt.onion/10.1039/c1lc20758j
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C4892121!4892121 !22037591
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suck abstract from ncbi


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pmid22037591
      Lab+Chip 2011 ; 11 (24 ): 4274-8
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  • Two-dimensional paper networks: programmable fluidic disconnects for multi-step processes in shaped paper #MMPMID22037591
  • Lutz BR ; Trinh P ; Ball C ; Fu E ; Yager P
  • Lab Chip 2011[Dec]; 11 (24 ): 4274-8 PMID22037591 show ga
  • Most laboratory assays take advantage of multi-step protocols to achieve high performance, but conventional paper-based tests (e.g., lateral flow tests) are generally limited to assays that can be carried out in a single fluidic step. We have developed two-dimensional paper networks (2DPNs) that use materials from lateral flow tests but reconfigure them to enable programming of multi-step reagent delivery sequences. The 2DPN uses multiple converging fluid inlets to control the arrival time of each fluid to a detection zone or reaction zone, and it requires a method to disconnect each fluid source in a corresponding timed sequence. Here, we present a method that allows programmed disconnection of fluid sources required for multi-step delivery. A 2DPN with legs of different lengths is inserted into a shared buffer well, and the dropping fluid surface disconnects each leg at in a programmable sequence. This approach could enable multi-step laboratory assays to be converted into simple point-of-care devices that have high performance yet remain easy to use.
  • |*Paper [MESH]
  • |Automation [MESH]
  • |Equipment Design [MESH]
  • |Microfluidic Analytical Techniques/*instrumentation [MESH]
  • |Point-of-Care Systems [MESH]


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