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10.3109/10409238.2015.1087960

http://scihub22266oqcxt.onion/10.3109/10409238.2015.1087960
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C4891981!4891981!26392149
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suck abstract from ncbi


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pmid26392149      Crit+Rev+Biochem+Mol+Biol 2015 ; 50 (6): 503-19
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  • RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications #MMPMID26392149
  • Xu L; Wang W; Chong J; Shin JH; Xu J; Wang D
  • Crit Rev Biochem Mol Biol 2015[]; 50 (6): 503-19 PMID26392149show ga
  • Accurate genetic information transfer is essential for life. As a key enzyme involved in the first step of gene expression, RNA polymerase II (Pol II) must maintain high transcriptional fidelity while it reads along DNA template and synthesizes RNA transcript in a stepwise manner during transcription elongation. DNA lesions or modifications may lead to significant changes in transcriptional fidelity or transcription elongation dynamics. In this review, we will summarize recent progress towards understanding the molecular basis of RNA Pol II transcriptional fidelity control and impacts of DNA lesions and modifications on Pol II transcription elongation.
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