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2016 ; 7
(ä): 32
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Generation of open biomedical datasets through ontology-driven transformation and
integration processes
#MMPMID27255189
Carmen Legaz-García MD
; Miñarro-Giménez JA
; Menárguez-Tortosa M
; Fernández-Breis JT
J Biomed Semantics
2016[Jun]; 7
(ä): 32
PMID27255189
show ga
BACKGROUND: Biomedical research usually requires combining large volumes of data
from multiple heterogeneous sources, which makes difficult the integrated
exploitation of such data. The Semantic Web paradigm offers a natural
technological space for data integration and exploitation by generating content
readable by machines. Linked Open Data is a Semantic Web initiative that promotes
the publication and sharing of data in machine readable semantic formats.
METHODS: We present an approach for the transformation and integration of
heterogeneous biomedical data with the objective of generating open biomedical
datasets in Semantic Web formats. The transformation of the data is based on the
mappings between the entities of the data schema and the ontological
infrastructure that provides the meaning to the content. Our approach permits
different types of mappings and includes the possibility of defining complex
transformation patterns. Once the mappings are defined, they can be automatically
applied to datasets to generate logically consistent content and the mappings can
be reused in further transformation processes. RESULTS: The results of our
research are (1) a common transformation and integration process for
heterogeneous biomedical data; (2) the application of Linked Open Data principles
to generate interoperable, open, biomedical datasets; (3) a software tool, called
SWIT, that implements the approach. In this paper we also describe how we have
applied SWIT in different biomedical scenarios and some lessons learned.
CONCLUSIONS: We have presented an approach that is able to generate open
biomedical repositories in Semantic Web formats. SWIT is able to apply the Linked
Open Data principles in the generation of the datasets, so allowing for linking
their content to external repositories and creating linked open datasets. SWIT
datasets may contain data from multiple sources and schemas, thus becoming
integrated datasets.