Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

http://scihub22266oqcxt.onion/ C4891457!4891457!27347352     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transl+Res 2016 ; 8 (5): 2432-7 Nephropedia Template TP {{tp|p=27347352|t=2016. Exosome-mediated transfer from the tumor microenvironment increases TGF? signaling in squamous cell carcinoma |pdf=|usr=}}{{27347352}} gab.com Text Exosome-mediated transfer from the tumor microenvironment increases TGF signaling in squamous cell carcinoma JO: Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=27347352 #FOAvip Transforming growth factor-beta (TGF?) signaling in cancer is context dependent and acts either as a tumor suppressor or a tumor promoter. Loss of function mutation in TGF? type II receptor (T?RII) is a frequent event in oral cavity squamous cell carcinoma (SCC). Recently, heterogeneity of TGF? response has been described at the leading edge of SCC and this heterogeneity has been shown to influence stem cell renewal and drug resistance. Because exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways we investigated whether exosomes contain components of the TGF? signaling pathway and whether exosome transfer between stromal fibroblasts and tumor cells can influence TGF? signaling in SCC. We demonstrate that exosomes purified from stromal fibroblasts isolated from patients with oral SCC contains T?RII. We also demonstrate that transfer of fibroblast exosomes increases TGF? signaling in SCC keratinocytes devoid of T?RII which remain non-responsive to TGF? ligand in the absence of exosome transfer. Overall our data show that stromal communication with tumor cells can direct TGF? signaling in SCC. Twit Text FOAVip Exosome-mediated transfer from the tumor microenvironment increases TGF signaling in squamous cell carcinoma ????Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=27347352 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27347352 #FOAvip English Wikipedia <ref>{{Cite pmid|27347352}}</ref> Exosome-mediated transfer from the tumor microenvironment increases TGF? signaling in squamous cell carcinoma #MMPMID27347352 Languino LR; Singh A; Prisco M; Inman GJ; Luginbuhl A; Curry JM; South AP Am J Transl Res 2016[]; 8 (5): 2432-7 PMID27347352show ga Transforming growth factor-beta (TGF?) signaling in cancer is context dependent and acts either as a tumor suppressor or a tumor promoter. Loss of function mutation in TGF? type II receptor (T?RII) is a frequent event in oral cavity squamous cell carcinoma (SCC). Recently, heterogeneity of TGF? response has been described at the leading edge of SCC and this heterogeneity has been shown to influence stem cell renewal and drug resistance. Because exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways we investigated whether exosomes contain components of the TGF? signaling pathway and whether exosome transfer between stromal fibroblasts and tumor cells can influence TGF? signaling in SCC. We demonstrate that exosomes purified from stromal fibroblasts isolated from patients with oral SCC contains T?RII. We also demonstrate that transfer of fibroblast exosomes increases TGF? signaling in SCC keratinocytes devoid of T?RII which remain non-responsive to TGF? ligand in the absence of exosome transfer. Overall our data show that stromal communication with tumor cells can direct TGF? signaling in SCC. äExosome-mediated transfer from the tumor microenvironment increases TG(epmc).pdf DeepDyve Pubget Overpricing