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10.1097/MNH.0000000000000229 http://scihub22266oqcxt.onion/10.1097/MNH.0000000000000229 C4891250!4891250!27191349     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Nephrol+Hypertens 2016 ; 25 (4): 363-71 Nephropedia Template TP {{tp|p=27191349|t=2016. Oxalate, inflammasome, and progression of kidney disease |pdf=|usr=}}{{27191349}} gab.com Text Oxalate, inflammasome, and progression of kidney disease JO: Curr Opin Nephrol Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=27191349 #FOAvip Purpose of review: Oxalate is an end product of metabolism excreted via the kidney. Excess urinary oxalate, whether from primary or enteric hyperoxaluria, can lead to oxalate deposition in the kidney. Oxalate crystals are associated with renal inflammation, fibrosis and progressive renal failure. It has long been known that as glomerular filtration rate (GFR) becomes reduced in chronic kidney disease (CKD), there is striking elevation of plasma oxalate. Taken together, these findings raise the possibility that elevation of plasma oxalate in CKD may promote renal inflammation and more rapid progression of CKD independent of primary etiology. Recent findings: The inflammasome has recently been identified to play a critical role in oxalate-induced renal inflammation. Oxalate crystals have been shown to activate the nucleotide-binding domain, leucine-rich repeat inflammasome 3 (also known as NALP3, NLRP3 or cryopyrin), resulting in release of Interleukin-1? and macrophage infiltration. Deletion of inflammasome proteins in mice protects from oxalate-induced renal inflammation and progressive renal failure. Summary: The findings reviewed in this article expand our understanding of the relevance of elevated plasma oxalate levels leading to inflammasome activation. We propose that inhibiting oxalate-induced inflammasome activation, or lowering plasma oxalate, may prevent or mitigate progressive renal damage in CKD, and warrants clinical trials. Twit Text FOAVip Oxalate, inflammasome, and progression of kidney disease ????Curr Opin Nephrol Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=27191349 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27191349 #FOAvip English Wikipedia <ref>{{Cite pmid|27191349}}</ref> Oxalate, inflammasome, and progression of kidney disease #MMPMID27191349 Ermer T; Eckardt KU; Aronson PS; Knauf F Curr Opin Nephrol Hypertens 2016[Jul]; 25 (4): 363-71 PMID27191349show ga Purpose of review: Oxalate is an end product of metabolism excreted via the kidney. Excess urinary oxalate, whether from primary or enteric hyperoxaluria, can lead to oxalate deposition in the kidney. Oxalate crystals are associated with renal inflammation, fibrosis and progressive renal failure. It has long been known that as glomerular filtration rate (GFR) becomes reduced in chronic kidney disease (CKD), there is striking elevation of plasma oxalate. Taken together, these findings raise the possibility that elevation of plasma oxalate in CKD may promote renal inflammation and more rapid progression of CKD independent of primary etiology. Recent findings: The inflammasome has recently been identified to play a critical role in oxalate-induced renal inflammation. Oxalate crystals have been shown to activate the nucleotide-binding domain, leucine-rich repeat inflammasome 3 (also known as NALP3, NLRP3 or cryopyrin), resulting in release of Interleukin-1? and macrophage infiltration. Deletion of inflammasome proteins in mice protects from oxalate-induced renal inflammation and progressive renal failure. Summary: The findings reviewed in this article expand our understanding of the relevance of elevated plasma oxalate levels leading to inflammasome activation. We propose that inhibiting oxalate-induced inflammasome activation, or lowering plasma oxalate, may prevent or mitigate progressive renal damage in CKD, and warrants clinical trials. äOxalate, inflammasome, and progression of kidney disease (epmc).pdf DeepDyve Pubget Overpricing