Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1158/0008-5472.CAN-15-2317 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-15-2317 C4891241!4891241!26988989     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2016 ; 76 (11): 3236-51 Nephropedia Template TP {{tp|p=26988989|t=2016. ?Np63? silences a microRNA program to aberrantly initiate a wound healing program that promotes TGF?-induced metastasis |pdf=|usr=}}{{26988989}} gab.com Text Np63 silences a microRNA program to aberrantly initiate a wound healing program that promotes TGF -induced metastasis JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26988989 #FOAvip Primary cancer cell dissemination is a key event during the metastatic cascade, but context-specific determinants of this process remain largely undefined. Multiple reports have suggested that the p53 (TP53) family member p63 (TP63) plays an anti-metastatic role through its minor epithelial isoform containing the N-terminal transactivation domain (TAp63). However, the role and contribution of the major p63 isoform lacking this domain, ?Np63?, remain largely undefined. Here, we report a distinct and TAp63-independent mechanism by which ?Np63?-expressing cells within a TGF?-rich microenvironment become positively selected for metastatic dissemination. Orthotopic transplantation of ?Np63?-expressing human osteosarcoma cells into athymic mice resulted in larger and more frequent lung metastases than transplantation of control cells. Mechanistic investigations revealed that ?Np63? repressed miR-527 and miR-665, leading to the upregulation of two TGF? effectors, SMAD4 and T?RII (TGFBR2). Furthermore, we provide evidence that this mechanism reflects a fundamental role for ?Np63? in the normal wound healing response. We show that ?Np63?-mediated repression of miR-527/665 controls a TGF?-dependent signaling node that switches off anti-migratory miR-198 by suppressing the expression of the regulatory factor, KSRP (KHSRP). Collectively, these findings reveal that a novel microRNA network involved in the regulation of physiological wound healing responses is hijacked and suppressed by tumor cells to promote metastatic dissemination. Twit Text FOAVip Np63 silences a microRNA program to aberrantly initiate a wound healing program that promotes TGF -induced metastasis ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26988989 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26988989 #FOAvip English Wikipedia <ref>{{Cite pmid|26988989}}</ref> ?Np63? silences a microRNA program to aberrantly initiate a wound healing program that promotes TGF?-induced metastasis #MMPMID26988989 Calleja LR; Jacques C; Lamoureux F; Baud'huin M; Gabriel MT; Quillard T; Sahay D; Perrot P; Amiaud J; Charrier C; Brion R; Lecanda F; Verrecchia F; Heymann D; Ellisen LW; Ory B Cancer Res 2016[Jun]; 76 (11): 3236-51 PMID26988989show ga Primary cancer cell dissemination is a key event during the metastatic cascade, but context-specific determinants of this process remain largely undefined. Multiple reports have suggested that the p53 (TP53) family member p63 (TP63) plays an anti-metastatic role through its minor epithelial isoform containing the N-terminal transactivation domain (TAp63). However, the role and contribution of the major p63 isoform lacking this domain, ?Np63?, remain largely undefined. Here, we report a distinct and TAp63-independent mechanism by which ?Np63?-expressing cells within a TGF?-rich microenvironment become positively selected for metastatic dissemination. Orthotopic transplantation of ?Np63?-expressing human osteosarcoma cells into athymic mice resulted in larger and more frequent lung metastases than transplantation of control cells. Mechanistic investigations revealed that ?Np63? repressed miR-527 and miR-665, leading to the upregulation of two TGF? effectors, SMAD4 and T?RII (TGFBR2). Furthermore, we provide evidence that this mechanism reflects a fundamental role for ?Np63? in the normal wound healing response. We show that ?Np63?-mediated repression of miR-527/665 controls a TGF?-dependent signaling node that switches off anti-migratory miR-198 by suppressing the expression of the regulatory factor, KSRP (KHSRP). Collectively, these findings reveal that a novel microRNA network involved in the regulation of physiological wound healing responses is hijacked and suppressed by tumor cells to promote metastatic dissemination. ä?Np63? silences a microRNA program to aberrantly initiate a wound heal(epmc).pdf DeepDyve Pubget Overpricing