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10.7554/eLife.12717 http://scihub22266oqcxt.onion/10.7554/eLife.12717 C4891180!4891180 !27178982     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27178982 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Elife 2016 ; 5 (ä): ä Nephropedia Template TP {{tp|p=27178982 |t=2016. Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition |pdf=|usr=}}{{27178982 }} gab.com Text Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=27178982 #FOAvip In the developing mammalian brain, differentiating neurons mature morphologically via neuronal polarity programs. Despite discovery of polarity pathways acting concurrently with differentiation, it's unclear how neurons traverse complex polarity transitions or how neuronal progenitors delay polarization during development. We report that zinc finger and homeobox transcription factor-1 (Zeb1), a master regulator of epithelial polarity, controls neuronal differentiation by transcriptionally repressing polarity genes in neuronal progenitors. Necessity-sufficiency testing and functional target screening in cerebellar granule neuron progenitors (GNPs) reveal that Zeb1 inhibits polarization and retains progenitors in their germinal zone (GZ). Zeb1 expression is elevated in the Sonic Hedgehog (SHH) medulloblastoma subgroup originating from GNPs with persistent SHH activation. Restored polarity signaling promotes differentiation and rescues GZ exit, suggesting a model for future differentiative therapies. These results reveal unexpected parallels between neuronal differentiation and mesenchymal-to-epithelial transition and suggest that active polarity inhibition contributes to altered GZ exit in pediatric brain cancers. Twit Text FOAVip Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=27178982 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27178982 #FOAvip English Wikipedia <ref>{{Cite pmid|27178982 }}</ref> Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition #MMPMID27178982 Singh S ; Howell D ; Trivedi N ; Kessler K ; Ong T ; Rosmaninho P ; Raposo AA ; Robinson G ; Roussel MF ; Castro DS ; Solecki DJ Elife 2016[May]; 5 (ä): ä PMID27178982 show ga In the developing mammalian brain, differentiating neurons mature morphologically via neuronal polarity programs. Despite discovery of polarity pathways acting concurrently with differentiation, it's unclear how neurons traverse complex polarity transitions or how neuronal progenitors delay polarization during development. We report that zinc finger and homeobox transcription factor-1 (Zeb1), a master regulator of epithelial polarity, controls neuronal differentiation by transcriptionally repressing polarity genes in neuronal progenitors. Necessity-sufficiency testing and functional target screening in cerebellar granule neuron progenitors (GNPs) reveal that Zeb1 inhibits polarization and retains progenitors in their germinal zone (GZ). Zeb1 expression is elevated in the Sonic Hedgehog (SHH) medulloblastoma subgroup originating from GNPs with persistent SHH activation. Restored polarity signaling promotes differentiation and rescues GZ exit, suggesting a model for future differentiative therapies. These results reveal unexpected parallels between neuronal differentiation and mesenchymal-to-epithelial transition and suggest that active polarity inhibition contributes to altered GZ exit in pediatric brain cancers. |*Cell Differentiation [MESH] |*Gene Expression Regulation, Developmental [MESH] |Animals [MESH] |Brain/embryology [MESH] |Mice [MESH] |Neurons/*physiology [MESH]Zeb1 controls neuron differentiation and germinal zone exit by a mes(epmc).pdf DeepDyve Pubget Overpricing