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10.18632/oncotarget.7186 http://scihub22266oqcxt.onion/10.18632/oncotarget.7186 C4891112!4891112 !26862731     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26862731 &cmd=llinks): Failed to open stream: HTTP request failed! 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Chromothripsis-like chromosomal rearrangements induced by ionizing radiation using proton microbeam irradiation system |pdf=|usr=}}{{26862731 }} gab.com Text Chromothripsis-like chromosomal rearrangements induced by ionizing radiation using proton microbeam irradiation system JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26862731 #FOAvip Chromothripsis is the massive but highly localized chromosomal rearrangement in response to a one-step catastrophic event, rather than an accumulation of a series of subsequent and random alterations. Chromothripsis occurs commonly in various human cancers and is thought to be associated with increased malignancy and carcinogenesis. However, the causes and consequences of chromothripsis remain unclear. Therefore, to identify the mechanism underlying the generation of chromothripsis, we investigated whether chromothripsis could be artificially induced by ionizing radiation. We first elicited DNA double-strand breaks in an oral squamous cell carcinoma cell line HOC313-P and its highly metastatic subline HOC313-LM, using Single Particle Irradiation system to Cell (SPICE), a focused vertical microbeam system designed to irradiate a spot within the nuclei of adhesive cells, and then established irradiated monoclonal sublines from them, respectively. SNP array analysis detected a number of chromosomal copy number alterations (CNAs) in these sublines, and one HOC313-LM-derived monoclonal subline irradiated with 200 protons by the microbeam displayed multiple CNAs involved locally in chromosome 7. Multi-color FISH showed a complex translocation of chromosome 7 involving chromosomes 11 and 12. Furthermore, whole genome sequencing analysis revealed multiple de novo complex chromosomal rearrangements localized in chromosomes 2, 5, 7, and 20, resembling chromothripsis. These findings suggested that localized ionizing irradiation within the nucleus may induce chromothripsis-like complex chromosomal alterations via local DNA damage in the nucleus. Twit Text FOAVip Chromothripsis-like chromosomal rearrangements induced by ionizing radiation using proton microbeam irradiation system ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26862731 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26862731 #FOAvip English Wikipedia <ref>{{Cite pmid|26862731 }}</ref> Chromothripsis-like chromosomal rearrangements induced by ionizing radiation using proton microbeam irradiation system #MMPMID26862731 Morishita M ; Muramatsu T ; Suto Y ; Hirai M ; Konishi T ; Hayashi S ; Shigemizu D ; Tsunoda T ; Moriyama K ; Inazawa J Oncotarget 2016[Mar]; 7 (9 ): 10182-92 PMID26862731 show ga Chromothripsis is the massive but highly localized chromosomal rearrangement in response to a one-step catastrophic event, rather than an accumulation of a series of subsequent and random alterations. Chromothripsis occurs commonly in various human cancers and is thought to be associated with increased malignancy and carcinogenesis. However, the causes and consequences of chromothripsis remain unclear. Therefore, to identify the mechanism underlying the generation of chromothripsis, we investigated whether chromothripsis could be artificially induced by ionizing radiation. We first elicited DNA double-strand breaks in an oral squamous cell carcinoma cell line HOC313-P and its highly metastatic subline HOC313-LM, using Single Particle Irradiation system to Cell (SPICE), a focused vertical microbeam system designed to irradiate a spot within the nuclei of adhesive cells, and then established irradiated monoclonal sublines from them, respectively. SNP array analysis detected a number of chromosomal copy number alterations (CNAs) in these sublines, and one HOC313-LM-derived monoclonal subline irradiated with 200 protons by the microbeam displayed multiple CNAs involved locally in chromosome 7. Multi-color FISH showed a complex translocation of chromosome 7 involving chromosomes 11 and 12. Furthermore, whole genome sequencing analysis revealed multiple de novo complex chromosomal rearrangements localized in chromosomes 2, 5, 7, and 20, resembling chromothripsis. These findings suggested that localized ionizing irradiation within the nucleus may induce chromothripsis-like complex chromosomal alterations via local DNA damage in the nucleus. |*Chromothripsis [MESH] |*Radiation, Ionizing [MESH] |Carcinoma, Squamous Cell/genetics [MESH] |Cell Line [MESH] |Cell Nucleus/genetics/*radiation effects [MESH] |Chromosome Aberrations/*radiation effects [MESH] |DNA Breaks, Double-Stranded/*radiation effects [MESH] |DNA Copy Number Variations/genetics [MESH] |DNA End-Joining Repair/genetics [MESH] |Gene Rearrangement/*radiation effects [MESH] |Humans [MESH] |Mouth Neoplasms/genetics [MESH]Chromothripsis-like chromosomal rearrangements induced by ionizing rad(epmc).pdf DeepDyve Pubget Overpricing