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10.18632/oncotarget.7015 http://scihub22266oqcxt.onion/10.18632/oncotarget.7015 C4891100!4891100 !26824420     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26824420 &cmd=llinks): Failed to open stream: HTTP request failed! 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ACTP: A webserver for predicting potential targets and relevant pathways of autophagy-modulating compounds |pdf=|usr=}}{{26824420 }} gab.com Text ACTP: A webserver for predicting potential targets and relevant pathways of autophagy-modulating compounds JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26824420 #FOAvip Autophagy (macroautophagy) is well known as an evolutionarily conserved lysosomal degradation process for long-lived proteins and damaged organelles. Recently, accumulating evidence has revealed a series of small-molecule compounds that may activate or inhibit autophagy for therapeutic potential on human diseases. However, targeting autophagy for drug discovery still remains in its infancy. In this study, we developed a webserver called Autophagic Compound-Target Prediction (ACTP) (http://actp.liu-lab.com/) that could predict autophagic targets and relevant pathways for a given compound. The flexible docking of submitted small-molecule compound (s) to potential autophagic targets could be performed by backend reverse docking. The webpage would return structure-based scores and relevant pathways for each predicted target. Thus, these results provide a basis for the rapid prediction of potential targets/pathways of possible autophagy-activating or autophagy-inhibiting compounds without labor-intensive experiments. Moreover, ACTP will be helpful to shed light on identifying more novel autophagy-activating or autophagy-inhibiting compounds for future therapeutic implications. Twit Text FOAVip ACTP: A webserver for predicting potential targets and relevant pathways of autophagy-modulating compounds ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26824420 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26824420 #FOAvip English Wikipedia <ref>{{Cite pmid|26824420 }}</ref> ACTP: A webserver for predicting potential targets and relevant pathways of autophagy-modulating compounds #MMPMID26824420 Xie T ; Zhang L ; Zhang S ; Ouyang L ; Cai H ; Liu B Oncotarget 2016[Mar]; 7 (9 ): 10015-22 PMID26824420 show ga Autophagy (macroautophagy) is well known as an evolutionarily conserved lysosomal degradation process for long-lived proteins and damaged organelles. Recently, accumulating evidence has revealed a series of small-molecule compounds that may activate or inhibit autophagy for therapeutic potential on human diseases. However, targeting autophagy for drug discovery still remains in its infancy. In this study, we developed a webserver called Autophagic Compound-Target Prediction (ACTP) (http://actp.liu-lab.com/) that could predict autophagic targets and relevant pathways for a given compound. The flexible docking of submitted small-molecule compound (s) to potential autophagic targets could be performed by backend reverse docking. The webpage would return structure-based scores and relevant pathways for each predicted target. Thus, these results provide a basis for the rapid prediction of potential targets/pathways of possible autophagy-activating or autophagy-inhibiting compounds without labor-intensive experiments. Moreover, ACTP will be helpful to shed light on identifying more novel autophagy-activating or autophagy-inhibiting compounds for future therapeutic implications. |Antibiotics, Antineoplastic/chemistry/metabolism/pharmacology [MESH] |Autophagy/*drug effects [MESH] |Binding Sites [MESH] |Computational Biology/*methods [MESH] |Drug Discovery/methods [MESH] |Humans [MESH] |Internet [MESH] |Molecular Docking Simulation [MESH] |Molecular Structure [MESH] |Molecular Targeted Therapy/methods [MESH] |Protein Binding [MESH] |Protein Domains [MESH] |Proteins/*antagonists & inhibitors/chemistry/metabolism [MESH] |Reproducibility of Results [MESH] |Signal Transduction/*drug effects [MESH] |Sirolimus/chemistry/metabolism/pharmacology [MESH] |Small Molecule Libraries/chemistry/metabolism/*pharmacology [MESH] |TOR Serine-Threonine Kinases/antagonists & inhibitors/chemistry/metabolism [MESH]ACTP: A webserver for predicting potential targets and relevant pathwa(epmc).pdf DeepDyve Pubget Overpricing