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A follow-up analysis of positron emission tomography/computed tomography in
detecting hidden malignancies at the time of diagnosis of membranous nephropathy
#MMPMID27009881
Feng Z
; Wang S
; Huang Y
; Liang X
; Shi W
; Zhang B
Oncotarget
2016[Mar]; 7
(9
): 9645-51
PMID27009881
show ga
Membranous nephropathy (MN) is the most common kidney disease reported in a
variety of malignant diseases. Search for an occult malignancy in MN has
presented special challenges. 124 MN patients with a physical examination not
suspicious for cancer underwent screening for an occult malignancy with either
18F-Fluorodeoxyglucose positron emission tomography/computed tomography
(FDG-PET/CT) scanning (n = 49) or conventional screening (n = 75) at the time of
diagnosis of MN, and were followed up (median,28 months). 154 patients who
refused to undergo any screening were followed up (median, 30 months). In
FDG-PET/CT cohort, 5 (10.20%) patients were screened and confirmed as malignancy,
in contrast, 1 (1.33%) patient in conventional screening cohort. During
follow-up, none of malignancy was detected in FDG-PET/CT cohort, 3(4.05%)
patients in conventional screening cohort, and 8(5.19%) patients in no-screening
cohort. All 6 cases of cancer were detected at early stages and underwent
curative resection, and after the resection, proteinuria decreased. In contrast,
11 cases of cancer detected during follow-up died without any remission of
proteinuria. These preliminary data provide the first evidence for a potential
cancer surveillance that the malignancy screening either through conventional or
by PET-CT at the diagnosis of MN led to an early diagnosis and curative
treatment.
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