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10.18632/oncotarget.6672 http://scihub22266oqcxt.onion/10.18632/oncotarget.6672 C4891057!4891057 !26848615     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26848615 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Notch pathway promotes the cancer stem cell characteristics of CD90+ cells in hepatocellular carcinoma |pdf=|usr=}}{{26848615 }} gab.com Text The Notch pathway promotes the cancer stem cell characteristics of CD90+ cells in hepatocellular carcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26848615 #FOAvip CD90 has been identified as a marker for liver cancer stem cells (CSCs) that are responsible for tumorigenic activity, but it is not known how CD90+ cells contribute to tumor initiation and progression. Our data demonstrated that high expression of CD90 in Hepatocellular Carcinoma (HCC) tissues correlated with venous filtration in HCC patients. CD90+ cells isolated from HCC cell lines exhibited increased tumorigenicity, chemoresistance, tumor invasion and metastasis. Notch pathway was activated in CD90+ cells and we found that inhibition of Notch pathway in CD90+ CSCs decreased tumorigenicity, cell invasion, migration and expression of stem cell related genes. Activation of Notch pathway in CD90- cells induced self-renewal, invasion and migration. Furthermore, we observed that cancer stem cell features were facilitated by stimulating G1-S transition in the cell cycle phase and inhibiting apoptosis mediated by Notch pathway. Our findings suggested CD90 could be used as a potential biomarker for HCC CSCs, and that cancer stem cell activity was elevated through up activated Notch pathway in CD90+ CSCs. Twit Text FOAVip The Notch pathway promotes the cancer stem cell characteristics of CD90+ cells in hepatocellular carcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26848615 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26848615 #FOAvip English Wikipedia <ref>{{Cite pmid|26848615 }}</ref> The Notch pathway promotes the cancer stem cell characteristics of CD90+ cells in hepatocellular carcinoma #MMPMID26848615 Luo J ; Wang P ; Wang R ; Wang J ; Liu M ; Xiong S ; Li Y ; Cheng B Oncotarget 2016[Feb]; 7 (8 ): 9525-37 PMID26848615 show ga CD90 has been identified as a marker for liver cancer stem cells (CSCs) that are responsible for tumorigenic activity, but it is not known how CD90+ cells contribute to tumor initiation and progression. Our data demonstrated that high expression of CD90 in Hepatocellular Carcinoma (HCC) tissues correlated with venous filtration in HCC patients. CD90+ cells isolated from HCC cell lines exhibited increased tumorigenicity, chemoresistance, tumor invasion and metastasis. Notch pathway was activated in CD90+ cells and we found that inhibition of Notch pathway in CD90+ CSCs decreased tumorigenicity, cell invasion, migration and expression of stem cell related genes. Activation of Notch pathway in CD90- cells induced self-renewal, invasion and migration. Furthermore, we observed that cancer stem cell features were facilitated by stimulating G1-S transition in the cell cycle phase and inhibiting apoptosis mediated by Notch pathway. Our findings suggested CD90 could be used as a potential biomarker for HCC CSCs, and that cancer stem cell activity was elevated through up activated Notch pathway in CD90+ CSCs. |Animals [MESH] |Apoptosis [MESH] |Biomarkers, Tumor [MESH] |Carcinoma, Hepatocellular/metabolism/*pathology [MESH] |Cell Line, Tumor [MESH] |Drug Resistance, Neoplasm [MESH] |Humans [MESH] |Liver Neoplasms/metabolism/*pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Mice, SCID [MESH] |Neoplasm Invasiveness/pathology [MESH] |Neoplasm Metastasis/pathology [MESH] |Neoplastic Stem Cells/*pathology [MESH] |Receptors, Notch/antagonists & inhibitors/*metabolism [MESH]The Notch pathway promotes the cancer stem cell characteristics of CD9(epmc).pdf DeepDyve Pubget Overpricing