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10.18632/oncotarget.6974 http://scihub22266oqcxt.onion/10.18632/oncotarget.6974 C4891041!4891041 !26814430     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26814430 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (8 ): 9296-308 Nephropedia Template TP {{tp|p=26814430 |t=2016. A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway |pdf=|usr=}}{{26814430 }} gab.com Text A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26814430 #FOAvip The oncogenic STAT3 signaling pathway is emerging as a promising target for the treatment of multiple myeloma (MM). In the present study, we identified a novel STAT3 inhibitor SC99 in a target-based high throughput screen. SC99 inhibited JAK2-STAT3 activation but had no effects on other transcription factors such as NF-?B, and kinases such as AKT, ERK, and c-Src that are in association with STAT3 signaling pathway. Furthermore, SC99 downregulated the expression of STAT3-modulated genes, including Bcl-2, Bcl-xL, VEGF, cyclin D2, and E2F-1. By inhibiting the STAT3 signaling, SC99 induced MM cell apoptosis which could be partly abolished by the ectopic expression of STAT3. Furthermore, SC99 displayed potent anti-MM activity in two independent MM xenograft models in nude mice. Oral administration of SC99 led to marked decrease of tumor growth within 10 days at a daily dosage of 30 mg/kg, but did not raise toxic effects. Taken together, this study identified a novel oral JAK2/STAT3 inhibitor that could be developed as an anti-myeloma agent. Twit Text FOAVip A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26814430 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26814430 #FOAvip English Wikipedia <ref>{{Cite pmid|26814430 }}</ref> A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway #MMPMID26814430 Zhang Z ; Mao H ; Du X ; Zhu J ; Xu Y ; Wang S ; Xu X ; Ji P ; Yu Y ; Cao B ; Han K ; Hou T ; Xu Z ; Kong Y ; Jiang G ; Tang X ; Qiao C ; Mao X Oncotarget 2016[Feb]; 7 (8 ): 9296-308 PMID26814430 show ga The oncogenic STAT3 signaling pathway is emerging as a promising target for the treatment of multiple myeloma (MM). In the present study, we identified a novel STAT3 inhibitor SC99 in a target-based high throughput screen. SC99 inhibited JAK2-STAT3 activation but had no effects on other transcription factors such as NF-?B, and kinases such as AKT, ERK, and c-Src that are in association with STAT3 signaling pathway. Furthermore, SC99 downregulated the expression of STAT3-modulated genes, including Bcl-2, Bcl-xL, VEGF, cyclin D2, and E2F-1. By inhibiting the STAT3 signaling, SC99 induced MM cell apoptosis which could be partly abolished by the ectopic expression of STAT3. Furthermore, SC99 displayed potent anti-MM activity in two independent MM xenograft models in nude mice. Oral administration of SC99 led to marked decrease of tumor growth within 10 days at a daily dosage of 30 mg/kg, but did not raise toxic effects. Taken together, this study identified a novel oral JAK2/STAT3 inhibitor that could be developed as an anti-myeloma agent. |3T3 Cells [MESH] |Animals [MESH] |Antineoplastic Agents/*therapeutic use [MESH] |Apoptosis/drug effects [MESH] |Cell Line, Tumor [MESH] |Cyclin D2/biosynthesis [MESH] |E2F1 Transcription Factor/biosynthesis [MESH] |Enzyme Activation/drug effects [MESH] |Female [MESH] |HeLa Cells [MESH] |Humans [MESH] |Hydrazones/*therapeutic use [MESH] |Janus Kinase 2/*antagonists & inhibitors [MESH] |Mice [MESH] |Mice, Nude [MESH] |Multiple Myeloma/*drug therapy/pathology [MESH] |Proto-Oncogene Proteins c-bcl-2/biosynthesis [MESH] |STAT3 Transcription Factor/*antagonists & inhibitors [MESH] |Signal Transduction/*drug effects [MESH] |Vascular Endothelial Growth Factor A/biosynthesis [MESH] |Xenograft Model Antitumor Assays [MESH]A novel small molecule agent displays potent anti-myeloma activity by (epmc).pdf DeepDyve Pubget Overpricing