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10.1016/bs.enz.2016.03.003 http://scihub22266oqcxt.onion/10.1016/bs.enz.2016.03.003 C4890617!4890617!27241932     free     free     free       Enzymes 2016 ; 39 (ä): 231-54 Nephropedia Template TP {{tp|p=27241932|t=2016. The many roles of PCNA in eukaryotic DNA replication |pdf=|usr=}}{{27241932}} gab.com Text The many roles of PCNA in eukaryotic DNA replication JO: Enzymes http://www.kidney.de/pget.php?&tw=1&pmid=27241932 #FOAvip Proliferating cell nuclear antigen (PCNA) plays critical roles in many aspects of DNA replication and replication-associated processes, including translesion synthesis, error-free damage bypass, break-induced replication, mismatch repair, and chromatin assembly. Since its discovery, our view of PCNA has evolved from a replication accessory factor to the hub protein in a large protein-protein interaction network that organizes and orchestrates many of the key events at the replication fork. We begin this review article with an overview of the structure and function of PCNA. We discuss the ways its many interacting partners bind and how these interactions are regulated by post-translational modifications such as ubiquitylation and sumoylation. We then explore the many roles of PCNA in normal DNA replication and in replication-coupled DNA damage tolerance and repair processes. We conclude by considering how PCNA can interact physically with so many binding partners to carry out its numerous roles. We propose that there is a large, dynamic network of linked PCNA molecules at and around the replication fork. This network would serve to increase the local concentration of all the proteins necessary for DNA replication and replication-associated processes and to regulate their various activities. Twit Text FOAVip The many roles of PCNA in eukaryotic DNA replication ????Enzymes http://www.kidney.de/pget.php?&tw=1&pmid=27241932 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27241932 #FOAvip English Wikipedia <ref>{{Cite pmid|27241932}}</ref> The many roles of PCNA in eukaryotic DNA replication #MMPMID27241932 Boehm EM; Gildenberg MS; Washington MT Enzymes 2016[]; 39 (ä): 231-54 PMID27241932show ga Proliferating cell nuclear antigen (PCNA) plays critical roles in many aspects of DNA replication and replication-associated processes, including translesion synthesis, error-free damage bypass, break-induced replication, mismatch repair, and chromatin assembly. Since its discovery, our view of PCNA has evolved from a replication accessory factor to the hub protein in a large protein-protein interaction network that organizes and orchestrates many of the key events at the replication fork. We begin this review article with an overview of the structure and function of PCNA. We discuss the ways its many interacting partners bind and how these interactions are regulated by post-translational modifications such as ubiquitylation and sumoylation. We then explore the many roles of PCNA in normal DNA replication and in replication-coupled DNA damage tolerance and repair processes. We conclude by considering how PCNA can interact physically with so many binding partners to carry out its numerous roles. We propose that there is a large, dynamic network of linked PCNA molecules at and around the replication fork. This network would serve to increase the local concentration of all the proteins necessary for DNA replication and replication-associated processes and to regulate their various activities. äThe many roles of PCNA in eukaryotic DNA replication (epmc).pdf DeepDyve Pubget Overpricing