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10.1016/j.celrep.2016.04.070 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.04.070 C4889555!4889555!27210761     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 15 (9): 1920-9 Nephropedia Template TP {{tp|p=27210761|t=2016. Identification of a Paralog-Specific Notch1 Intracellular Domain Degron |pdf=|usr=}}{{27210761}} gab.com Text Identification of a Paralog-Specific Notch1 Intracellular Domain Degron JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27210761 #FOAvip Upon Notch pathway activation, the receptor is cleaved to release the Notch intracellular domain (NICD), which translocates to the nucleus to activate gene transcription. Using Xenopus egg extracts, we have identified a Notch1-specific destruction signal (N1-Box). We show that mutations in the N1-Box inhibit NICD1 degradation and that the N1-Box is transferable for the promotion of degradation of heterologous proteins in Xenopus egg extracts and in cultured human cells. Mutation of the N1-Box enhances Notch1 activity in cultured human cells and zebrafish embryos. Human cancer mutations within the N1-Box enhance Notch1 signaling in transgenic zebrafish, highlighting the physiological relevance of this destruction signal. We find that binding of the Notch nuclear factor, CSL, to the N1-Box blocks NICD1 turnover. Our studies reveal a mechanism by which degradation of NICD1 is regulated by the N1-Box to minimize stochastic flux and to establish a threshold for Notch1 pathway activation. Twit Text FOAVip Identification of a Paralog-Specific Notch1 Intracellular Domain Degron ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27210761 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27210761 #FOAvip English Wikipedia <ref>{{Cite pmid|27210761}}</ref> Identification of a Paralog-Specific Notch1 Intracellular Domain Degron #MMPMID27210761 Broadus MR; Chen TW; Neitzel LR; Ng VH; Jodoin JN; Lee LA; Salic A; Robbins DJ; Capobianco AJ; Patton JG; Huppert SS; Lee E Cell Rep 2016[May]; 15 (9): 1920-9 PMID27210761show ga Upon Notch pathway activation, the receptor is cleaved to release the Notch intracellular domain (NICD), which translocates to the nucleus to activate gene transcription. Using Xenopus egg extracts, we have identified a Notch1-specific destruction signal (N1-Box). We show that mutations in the N1-Box inhibit NICD1 degradation and that the N1-Box is transferable for the promotion of degradation of heterologous proteins in Xenopus egg extracts and in cultured human cells. Mutation of the N1-Box enhances Notch1 activity in cultured human cells and zebrafish embryos. Human cancer mutations within the N1-Box enhance Notch1 signaling in transgenic zebrafish, highlighting the physiological relevance of this destruction signal. We find that binding of the Notch nuclear factor, CSL, to the N1-Box blocks NICD1 turnover. Our studies reveal a mechanism by which degradation of NICD1 is regulated by the N1-Box to minimize stochastic flux and to establish a threshold for Notch1 pathway activation. äIdentification of a Paralog-Specific Notch1 Intracellular Domain Degro(epmc).pdf DeepDyve Pubget Overpricing