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10.1016/j.celrep.2016.04.018 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.04.018 C4889529!4889529!27210747     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 15 (9): 2025-37 Nephropedia Template TP {{tp|p=27210747|t=2016. The lncRNA SLNCR1 mediates melanoma invasion through a conserved SRA1-like region |pdf=|usr=}}{{27210747}} gab.com Text The lncRNA SLNCR1 mediates melanoma invasion through a conserved SRA1-like region JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27210747 #FOAvip Long non-coding RNAs (lncRNAs) have been implicated in numerous physiological processes and diseases, most notably cancers. However, little is known about the mechanism of many functional lncRNAs. We identified an abundantly-expressed lncRNA associated with decreased melanoma patient survival. Increased expression of this lncRNA, SLNCR1, mediates melanoma invasion through a highly-conserved sequence similar to the lncRNA SRA1. Using a sensitive technique we term RATA (RNA-associated transcription factor array), we show that the brain-specific homeobox protein 3a (Brn3a) and the androgen receptor (AR) bind within and adjacent to SLNCR1?s conserved region, respectively. SLNCR1, AR, and Brn3a are specifically required for transcriptional activation of matrix metalloproteinase 9 (MMP9) and increased melanoma invasion. Our observations directly link AR to melanoma invasion, possibly explaining why males experience more melanoma metastases and have an overall lower survival as compared to females. Twit Text FOAVip The lncRNA SLNCR1 mediates melanoma invasion through a conserved SRA1-like region ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27210747 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27210747 #FOAvip English Wikipedia <ref>{{Cite pmid|27210747}}</ref> The lncRNA SLNCR1 mediates melanoma invasion through a conserved SRA1-like region #MMPMID27210747 Schmidt K; Joyce CE; Buquicchio F; Brown A; Ritz J; Distel RJ; Yoon CH; Novina CD Cell Rep 2016[May]; 15 (9): 2025-37 PMID27210747show ga Long non-coding RNAs (lncRNAs) have been implicated in numerous physiological processes and diseases, most notably cancers. However, little is known about the mechanism of many functional lncRNAs. We identified an abundantly-expressed lncRNA associated with decreased melanoma patient survival. Increased expression of this lncRNA, SLNCR1, mediates melanoma invasion through a highly-conserved sequence similar to the lncRNA SRA1. Using a sensitive technique we term RATA (RNA-associated transcription factor array), we show that the brain-specific homeobox protein 3a (Brn3a) and the androgen receptor (AR) bind within and adjacent to SLNCR1?s conserved region, respectively. SLNCR1, AR, and Brn3a are specifically required for transcriptional activation of matrix metalloproteinase 9 (MMP9) and increased melanoma invasion. Our observations directly link AR to melanoma invasion, possibly explaining why males experience more melanoma metastases and have an overall lower survival as compared to females. äThe lncRNA SLNCR1 mediates melanoma invasion through a conserved SRA1-(epmc).pdf DeepDyve Pubget Overpricing