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10.1016/j.celrep.2016.04.082 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.04.082 C4889506!4889506!27210760     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 15 (9): 1910-9 Nephropedia Template TP {{tp|p=27210760|t=2016. Atg5 is essential for the development and survival of innate lymphocytes |pdf=|usr=}}{{27210760}} gab.com Text Atg5 is essential for the development and survival of innate lymphocytes JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27210760 #FOAvip Autophagy is an essential cellular survival mechanism that is required for adaptive lymphocyte development; however, its role in innate lymphoid cell (ILC) development remains unknown. Furthermore, the conditions that promote lymphocyte autophagy during homeostasis are poorly understood. Here we demonstrate that Atg5, an essential component of the autophagy machinery, is required for the development of mature natural killer (NK) cells and group 1, 2, and 3 innate lymphoid cells (ILC). While inducible ablation of Atg5 was dispensable for the homeostasis of lymphocyte precursors and mature lymphocytes in lymphoreplete mice, we found that autophagy is induced in both adaptive and innate lymphocytes during homeostatic proliferation in lymphopenic hosts to promote their survival by limiting cell-intrinsic apoptosis. Induction of autophagy through metformin treatment following homeostatic proliferation increased lymphocyte numbers through an Atg5-dependent mechanism. These findings highlight the essential role for autophagy in ILC development and lymphocyte survival during lymphopenia. Twit Text FOAVip Atg5 is essential for the development and survival of innate lymphocytes ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27210760 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27210760 #FOAvip English Wikipedia <ref>{{Cite pmid|27210760}}</ref> Atg5 is essential for the development and survival of innate lymphocytes #MMPMID27210760 O?Sullivan TE; Geary CD; Weizman OE; Geiger TL; Rapp M; Dorn GW; Overholtzer M; Sun JC Cell Rep 2016[May]; 15 (9): 1910-9 PMID27210760show ga Autophagy is an essential cellular survival mechanism that is required for adaptive lymphocyte development; however, its role in innate lymphoid cell (ILC) development remains unknown. Furthermore, the conditions that promote lymphocyte autophagy during homeostasis are poorly understood. Here we demonstrate that Atg5, an essential component of the autophagy machinery, is required for the development of mature natural killer (NK) cells and group 1, 2, and 3 innate lymphoid cells (ILC). While inducible ablation of Atg5 was dispensable for the homeostasis of lymphocyte precursors and mature lymphocytes in lymphoreplete mice, we found that autophagy is induced in both adaptive and innate lymphocytes during homeostatic proliferation in lymphopenic hosts to promote their survival by limiting cell-intrinsic apoptosis. Induction of autophagy through metformin treatment following homeostatic proliferation increased lymphocyte numbers through an Atg5-dependent mechanism. These findings highlight the essential role for autophagy in ILC development and lymphocyte survival during lymphopenia. äAtg5 is essential for the development and survival of innate lymphocyt(epmc).pdf DeepDyve Pubget Overpricing