Mechanisms and Consequences of Entosis #MMPMID27048820
Krishna S; Overholtzer M
Cell Mol Life Sci 2016[Jun]; 73 (11-12): 2379-86 PMID27048820show ga
Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called ?cell-in-cell? structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis and development. Curiously, entotic cells participate actively in their own engulfment, by invading into their hosts, and are then killed non-cell-autonomously. Here we review the mechanisms of entosis and entotic cell death and the consequences of entosis on cell populations.