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10.1080/15384101.2016.1152427 http://scihub22266oqcxt.onion/10.1080/15384101.2016.1152427 C4889297!4889297!26940461     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Cycle 2016 ; 15 (7): 1009-18 Nephropedia Template TP {{tp|p=26940461|t=2016. Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-?B signaling |pdf=|usr=}}{{26940461}} gab.com Text Calorie restriction-induced SIRT6 activation delays aging by suppressing NF- B signaling JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=26940461 #FOAvip Calorie restriction (CR) extends lifespan from yeast to mammals. SIRT6 is a member of the sirtuin family of NAD+-dependent histone deacetylases, which is responsible for mediating the effects of CR. The transcription factor NF-?B, which is involved in inflammation and aging, has been shown to be regulated by SIRT6. Here we describe the crucial role of SIRT6 in aging and inflammation. We show that CR had improved renal insufficiency and enhanced SIRT6 expression after 6-month treatment in aged mice. Culture cells in low glucose (LG) conditions also showed resistance to cell senescence and enhanced SIRT6 expression compared to normal glucose (NG) group, showing beneficial effects of the CR-mimic cultural conditions. Moreover, SIRT6 overexpression is sufficient to delay the replicative senescence of WI38 by attenuating NF-?B signaling, while SIRT6 knockdown results in accelerated cell senescence and overactive NF-?B signaling. These findings confirm the key status of CR and disclose the critical role of SIRT6 on aging and inflammation. Twit Text FOAVip Calorie restriction-induced SIRT6 activation delays aging by suppressing NF- B signaling ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=26940461 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26940461 #FOAvip English Wikipedia <ref>{{Cite pmid|26940461}}</ref> Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-?B signaling #MMPMID26940461 Zhang N; Li Z; Mu W; Li L; Liang Y; Lu M; Wang Z; Qiu Y; Wang Z Cell Cycle 2016[]; 15 (7): 1009-18 PMID26940461show ga Calorie restriction (CR) extends lifespan from yeast to mammals. SIRT6 is a member of the sirtuin family of NAD+-dependent histone deacetylases, which is responsible for mediating the effects of CR. The transcription factor NF-?B, which is involved in inflammation and aging, has been shown to be regulated by SIRT6. Here we describe the crucial role of SIRT6 in aging and inflammation. We show that CR had improved renal insufficiency and enhanced SIRT6 expression after 6-month treatment in aged mice. Culture cells in low glucose (LG) conditions also showed resistance to cell senescence and enhanced SIRT6 expression compared to normal glucose (NG) group, showing beneficial effects of the CR-mimic cultural conditions. Moreover, SIRT6 overexpression is sufficient to delay the replicative senescence of WI38 by attenuating NF-?B signaling, while SIRT6 knockdown results in accelerated cell senescence and overactive NF-?B signaling. These findings confirm the key status of CR and disclose the critical role of SIRT6 on aging and inflammation. äCalorie restriction-induced SIRT6 activation delays aging by suppressi(epmc).pdf DeepDyve Pubget Overpricing