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10.1080/15384101.2016.1156267 http://scihub22266oqcxt.onion/10.1080/15384101.2016.1156267 C4889261!4889261!26940341     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Cycle 2016 ; 15 (8): 1073-83 Nephropedia Template TP {{tp|p=26940341|t=2016. T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4 |pdf=|usr=}}{{26940341}} gab.com Text T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4 JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=26940341 #FOAvip The clonal expansion of activated T cells is pivotal for the induction of protective immunity. Protein phosphatase 4 (PP4) is a ubiquitously expressed serine/threonine phosphatase with reported functions in thymocyte development and DNA damage responses. However, the role of PP4 in T cell immunity has not been thoroughly investigated. In this report, our data showed that T cell-specific ablation of PP4 resulted in defective adaptive immunity, impaired T cell homeostatic expansion, and inefficient T cell proliferation. This hypo-proliferation was associated with a partial G1-S cell cycle arrest, enhanced transcriptions of CDK inhibitors and elevated activation of AMPK. In addition, resveratrol, a known AMPK activator, induced similar G1-S arrests, while lentivirally-transduced WT or constitutively-active AMPK?1 retarded the proliferation of WT T cells. Further investigations showed that PP4 co-immunoprecipitated with AMPK?1, and the over-expression of PP4 inhibited AMPK phosphorylation, thereby implicating PP4 for the negative regulation of AMPK. In summary, our results indicate that PP4 is an essential modulator for T cell proliferation and immune responses; they further suggest a potential link between PP4 functions, AMPK activation and G1-S arrest in activated T cells. Twit Text FOAVip T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4 ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=26940341 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26940341 #FOAvip English Wikipedia <ref>{{Cite pmid|26940341}}</ref> T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4 #MMPMID26940341 Liao FH; Hsiao WY; Lin YC; Chan YC; Huang CY Cell Cycle 2016[]; 15 (8): 1073-83 PMID26940341show ga The clonal expansion of activated T cells is pivotal for the induction of protective immunity. Protein phosphatase 4 (PP4) is a ubiquitously expressed serine/threonine phosphatase with reported functions in thymocyte development and DNA damage responses. However, the role of PP4 in T cell immunity has not been thoroughly investigated. In this report, our data showed that T cell-specific ablation of PP4 resulted in defective adaptive immunity, impaired T cell homeostatic expansion, and inefficient T cell proliferation. This hypo-proliferation was associated with a partial G1-S cell cycle arrest, enhanced transcriptions of CDK inhibitors and elevated activation of AMPK. In addition, resveratrol, a known AMPK activator, induced similar G1-S arrests, while lentivirally-transduced WT or constitutively-active AMPK?1 retarded the proliferation of WT T cells. Further investigations showed that PP4 co-immunoprecipitated with AMPK?1, and the over-expression of PP4 inhibited AMPK phosphorylation, thereby implicating PP4 for the negative regulation of AMPK. In summary, our results indicate that PP4 is an essential modulator for T cell proliferation and immune responses; they further suggest a potential link between PP4 functions, AMPK activation and G1-S arrest in activated T cells. äT cell proliferation and adaptive immune responses are critically regu(epmc).pdf DeepDyve Pubget Overpricing