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10.1080/15384101.2016.1157238 http://scihub22266oqcxt.onion/10.1080/15384101.2016.1157238 C4889241!4889241!27082696     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Cycle 2016 ; 15 (9): 1189-201 Nephropedia Template TP {{tp|p=27082696|t=2016. The non-canonical functions of p27Kip1 in normal and tumor biology |pdf=|usr=}}{{27082696}} gab.com Text The non-canonical functions of p27Kip1 in normal and tumor biology JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=27082696 #FOAvip p27Kip1 was first discovered as a key regulator of cell proliferation. The canonical function of p27Kip1 is inhibition of cyclin-dependent kinase (CDK) activity. In addition to its initial identification as a CDK inhibitor, p27Kip1 has also emerged as an intrinsically unstructured, multifunctional protein with numerous non-canonical, CDK-independent functions that exert influence on key processes such as cell cycle regulation, cytoskeletal dynamics and cellular plasticity, cell migration, and stem-cell proliferation and differentiation. Many of these non-canonical functions, depending on the cell-specific contexts such as oncogenic activation of signaling pathways, have the ability to turn pro-oncogenic in nature and even contribute to tumor-aggressiveness and metastasis. This review discusses the various non-canonical, CDK-independent mechanisms by which p27Kip1 functions either as a tumor-suppressor or tumor-promoter. Twit Text FOAVip The non-canonical functions of p27Kip1 in normal and tumor biology ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=27082696 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27082696 #FOAvip English Wikipedia <ref>{{Cite pmid|27082696}}</ref> The non-canonical functions of p27Kip1 in normal and tumor biology #MMPMID27082696 Sharma SS; Pledger WJ Cell Cycle 2016[]; 15 (9): 1189-201 PMID27082696show ga p27Kip1 was first discovered as a key regulator of cell proliferation. The canonical function of p27Kip1 is inhibition of cyclin-dependent kinase (CDK) activity. In addition to its initial identification as a CDK inhibitor, p27Kip1 has also emerged as an intrinsically unstructured, multifunctional protein with numerous non-canonical, CDK-independent functions that exert influence on key processes such as cell cycle regulation, cytoskeletal dynamics and cellular plasticity, cell migration, and stem-cell proliferation and differentiation. Many of these non-canonical functions, depending on the cell-specific contexts such as oncogenic activation of signaling pathways, have the ability to turn pro-oncogenic in nature and even contribute to tumor-aggressiveness and metastasis. This review discusses the various non-canonical, CDK-independent mechanisms by which p27Kip1 functions either as a tumor-suppressor or tumor-promoter. äThe non-canonical functions of p27Kip1 in normal and tumor biology (epmc).pdf DeepDyve Pubget Overpricing