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10.1080/15384101.2016.1164371 http://scihub22266oqcxt.onion/10.1080/15384101.2016.1164371 C4889240!4889240!27052725     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Cycle 2016 ; 15 (10): 1325-30 Nephropedia Template TP {{tp|p=27052725|t=2016. The G protein G?s acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis |pdf=|usr=}}{{27052725}} gab.com Text The G protein G s acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=27052725 #FOAvip G protein-coupled receptors (GPCRs) are critical players in tumor growth and progression. The redundant roles of GPCRs in tumor development confound effective treatment; therefore, targeting a single common signaling component downstream of these receptors may be efficacious. GPCRs transmit signals through heterotrimeric G proteins composed of G? and G?? subunits. Hyperactive G?s signaling can mediate tumor progression in some tissues; however, recent work in medulloblastoma and basal cell carcinoma revealed that G?s can also function as a tumor suppressor in neoplasms derived from ectoderm cells including neural and epidermal stem/progenitor cells. In these stem-cell compartments, signaling through G?s suppresses self-renewal by inhibiting the Sonic Hedgehog (SHH) and Hippo pathways. The loss of GNAS, which encodes G?s, leads to activation of these pathways, over-proliferation of progenitor cells, and tumor formation. G?s activates the cAMP-dependent protein kinase A (PKA) signaling pathway and inhibits activation of SHH effectors Smoothened-Gli. In addition, G?s-cAMP-PKA activation negatively regulates the Hippo pathway by blocking the NF2-LATS1/2-Yap signaling. In this review, we will address the novel function of the signaling network regulated by G?s in suppression of SHH-driven tumorigenesis and the therapeutic approaches that can be envisioned to harness this pathway to inhibit tumor growth and progression. Twit Text FOAVip The G protein G s acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=27052725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27052725 #FOAvip English Wikipedia <ref>{{Cite pmid|27052725}}</ref> The G protein G?s acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis #MMPMID27052725 Rao R; Salloum R; Xin M; Lu QR Cell Cycle 2016[]; 15 (10): 1325-30 PMID27052725show ga G protein-coupled receptors (GPCRs) are critical players in tumor growth and progression. The redundant roles of GPCRs in tumor development confound effective treatment; therefore, targeting a single common signaling component downstream of these receptors may be efficacious. GPCRs transmit signals through heterotrimeric G proteins composed of G? and G?? subunits. Hyperactive G?s signaling can mediate tumor progression in some tissues; however, recent work in medulloblastoma and basal cell carcinoma revealed that G?s can also function as a tumor suppressor in neoplasms derived from ectoderm cells including neural and epidermal stem/progenitor cells. In these stem-cell compartments, signaling through G?s suppresses self-renewal by inhibiting the Sonic Hedgehog (SHH) and Hippo pathways. The loss of GNAS, which encodes G?s, leads to activation of these pathways, over-proliferation of progenitor cells, and tumor formation. G?s activates the cAMP-dependent protein kinase A (PKA) signaling pathway and inhibits activation of SHH effectors Smoothened-Gli. In addition, G?s-cAMP-PKA activation negatively regulates the Hippo pathway by blocking the NF2-LATS1/2-Yap signaling. In this review, we will address the novel function of the signaling network regulated by G?s in suppression of SHH-driven tumorigenesis and the therapeutic approaches that can be envisioned to harness this pathway to inhibit tumor growth and progression. äThe G protein G?s acts as a tumor suppressor in sonic hedgehog signali(epmc).pdf DeepDyve Pubget Overpricing