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10.1161/JAHA.115.003031 http://scihub22266oqcxt.onion/10.1161/JAHA.115.003031 C4889178!4889178!27207962     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Heart+Assoc 2016 ; 5 (5): ä Nephropedia Template TP {{tp|p=27207962|t=2016. NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis |pdf=|usr=}}{{27207962}} gab.com Text NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis JO: J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=27207962 #FOAvip Background: The NLR family, pyrin domain containing 3 (NLRP3) inflammasome is an interleukin (IL)?1? and IL?18 cytokine processing complex that is activated in inflammatory conditions. The role of the NLRP3 inflammasome in the pathogenesis of atherosclerosis and myocardial infarction is not fully understood. Methods and Results: Atherosclerotic plaques were analyzed for transcripts of the NLRP3 inflammasome, and for IL?1? release. The Swedish First?ever myocardial Infarction study in Ac?county (FIA) cohort consisting of DNA from 555 myocardial infarction patients and 1016 healthy individuals was used to determine the frequency of 4 single nucleotide polymorphisms (SNPs) from the downstream regulatory region of NLRP3. Expression of NLRP3, Apoptosis?associated speck?like protein containing a CARD (ASC), caspase?1 (CASP1), IL1B, and IL18 mRNA was significantly increased in atherosclerotic plaques compared to normal arteries. The expression of NLRP3 mRNA was significantly higher in plaques of symptomatic patients when compared to asymptomatic ones. CD68?positive macrophages were observed in the same areas of atherosclerotic lesions as NLRP3 and ASC expression. Occasionally, expression of NLRP3 and ASC was also present in smooth muscle cells. Cholesterol crystals and ATP induced IL?1? release from lipopolysaccharide?primed human atherosclerotic lesion plaques. The minor alleles of the variants rs4266924, rs6672995, and rs10733113 were associated with NLRP3 mRNA levels in peripheral blood mononuclear cells but not with the risk of myocardial infarction. Conclusions: Our results indicate a possible role of the NLRP3 inflammasome and its genetic variants in the pathogenesis of atherosclerosis. Twit Text FOAVip NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis ????J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=27207962 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27207962 #FOAvip English Wikipedia <ref>{{Cite pmid|27207962}}</ref> NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis #MMPMID27207962 Paramel Varghese G; Folkersen L; Strawbridge RJ; Halvorsen B; Yndestad A; Ranheim T; Krohg?Sørensen K; Skjelland M; Espevik T; Aukrust P; Lengquist M; Hedin U; Jansson J; Fransén K; Hansson GK; Eriksson P; Sirsjö A J Am Heart Assoc 2016[May]; 5 (5): ä PMID27207962show ga Background: The NLR family, pyrin domain containing 3 (NLRP3) inflammasome is an interleukin (IL)?1? and IL?18 cytokine processing complex that is activated in inflammatory conditions. The role of the NLRP3 inflammasome in the pathogenesis of atherosclerosis and myocardial infarction is not fully understood. Methods and Results: Atherosclerotic plaques were analyzed for transcripts of the NLRP3 inflammasome, and for IL?1? release. The Swedish First?ever myocardial Infarction study in Ac?county (FIA) cohort consisting of DNA from 555 myocardial infarction patients and 1016 healthy individuals was used to determine the frequency of 4 single nucleotide polymorphisms (SNPs) from the downstream regulatory region of NLRP3. Expression of NLRP3, Apoptosis?associated speck?like protein containing a CARD (ASC), caspase?1 (CASP1), IL1B, and IL18 mRNA was significantly increased in atherosclerotic plaques compared to normal arteries. The expression of NLRP3 mRNA was significantly higher in plaques of symptomatic patients when compared to asymptomatic ones. CD68?positive macrophages were observed in the same areas of atherosclerotic lesions as NLRP3 and ASC expression. Occasionally, expression of NLRP3 and ASC was also present in smooth muscle cells. Cholesterol crystals and ATP induced IL?1? release from lipopolysaccharide?primed human atherosclerotic lesion plaques. The minor alleles of the variants rs4266924, rs6672995, and rs10733113 were associated with NLRP3 mRNA levels in peripheral blood mononuclear cells but not with the risk of myocardial infarction. Conclusions: Our results indicate a possible role of the NLRP3 inflammasome and its genetic variants in the pathogenesis of atherosclerosis. äNLRP3 Inflammasome Expression and Activation in Human Atherosclerosis (epmc).pdf DeepDyve Pubget Overpricing