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10.1016/j.ccell.2016.03.007 http://scihub22266oqcxt.onion/10.1016/j.ccell.2016.03.007 C4889129!4889129!27070701     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Cell 2016 ; 29 (4): 464-76 Nephropedia Template TP {{tp|p=27070701|t=2016. Exploiting the epigenome to control cancer promoting gene expression programs |pdf=|usr=}}{{27070701}} gab.com Text Exploiting the epigenome to control cancer promoting gene expression programs JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=27070701 #FOAvip The epigenome is a key determinant of transcriptional output. Perturbations within the epigenome are thought to be a key feature of many, perhaps all cancers, and it is now clear that epigenetic changes are instrumental in cancer development. The inherent reversibility of these changes makes them attractive targets for therapeutic manipulation and a number of small molecules targeting chromatin-based mechanisms are currently in clinical trials. In this perspective we discuss how understanding the cancer epigenome is providing insights into disease pathogenesis and informing drug development. We also highlight additional opportunities to further unlock the therapeutic potential within the cancer epigenome. Twit Text FOAVip Exploiting the epigenome to control cancer promoting gene expression programs ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=27070701 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27070701 #FOAvip English Wikipedia <ref>{{Cite pmid|27070701}}</ref> Exploiting the epigenome to control cancer promoting gene expression programs #MMPMID27070701 Brien GL; Valerio DG; Armstrong SA Cancer Cell 2016[Apr]; 29 (4): 464-76 PMID27070701show ga The epigenome is a key determinant of transcriptional output. Perturbations within the epigenome are thought to be a key feature of many, perhaps all cancers, and it is now clear that epigenetic changes are instrumental in cancer development. The inherent reversibility of these changes makes them attractive targets for therapeutic manipulation and a number of small molecules targeting chromatin-based mechanisms are currently in clinical trials. In this perspective we discuss how understanding the cancer epigenome is providing insights into disease pathogenesis and informing drug development. We also highlight additional opportunities to further unlock the therapeutic potential within the cancer epigenome. äExploiting the epigenome to control cancer promoting gene expression p(epmc).pdf DeepDyve Pubget Overpricing