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10.1002/prca.201500102 http://scihub22266oqcxt.onion/10.1002/prca.201500102 C4888976!4888976!26703953     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26703953&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proteomics+Clin+Appl 2016 ; 10 (4): 358-70 Nephropedia Template TP {{tp|p=26703953|t=2016. Biomarker Discovery in Mass Spectrometry-based Urinary Proteomics |pdf=|usr=}}{{26703953}} gab.com Text Biomarker Discovery in Mass Spectrometry-based Urinary Proteomics JO: Proteomics Clin Appl http://www.kidney.de/pget.php?&tw=1&pmid=26703953 #FOAvip Urinary proteomics has become one of the most attractive topics in disease biomarker discovery. Mass spectrometry (MS)-based proteomic analysis has advanced continuously and emerged as a prominent tool in the field of clinical bioanalysis. However, only few protein biomarkers have made their way to validation and clinical practice. Biomarker discovery is challenged by many clinical and analytical factors including, but not limited to, the complexity of urine and the wide dynamic range of endogenous proteins in the sample. This article highlights promising technologies and strategies in the MS-based biomarker discovery process, including study design, sample preparation, protein quantification, instrumental platforms, and bioinformatics. Different proteomics approaches are discussed, and progresses in maximizing urinary proteome coverage and standardization are emphasized in this review. MS-based urinary proteomics has great potential in the development of noninvasive diagnostic assays in the future, which will require collaborative efforts between analytical scientists, systems biologists, and clinicians. Twit Text FOAVip Biomarker Discovery in Mass Spectrometry-based Urinary Proteomics ????Proteomics Clin Appl http://www.kidney.de/pget.php?&tw=1&pmid=26703953 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26703953 #FOAvip English Wikipedia <ref>{{Cite pmid|26703953}}</ref> Biomarker Discovery in Mass Spectrometry-based Urinary Proteomics #MMPMID26703953 Thomas S; Hao L; Ricke WA; Li L Proteomics Clin Appl 2016[Apr]; 10 (4): 358-70 PMID26703953show ga Urinary proteomics has become one of the most attractive topics in disease biomarker discovery. Mass spectrometry (MS)-based proteomic analysis has advanced continuously and emerged as a prominent tool in the field of clinical bioanalysis. However, only few protein biomarkers have made their way to validation and clinical practice. Biomarker discovery is challenged by many clinical and analytical factors including, but not limited to, the complexity of urine and the wide dynamic range of endogenous proteins in the sample. This article highlights promising technologies and strategies in the MS-based biomarker discovery process, including study design, sample preparation, protein quantification, instrumental platforms, and bioinformatics. Different proteomics approaches are discussed, and progresses in maximizing urinary proteome coverage and standardization are emphasized in this review. MS-based urinary proteomics has great potential in the development of noninvasive diagnostic assays in the future, which will require collaborative efforts between analytical scientists, systems biologists, and clinicians. äBiomarker Discovery in Mass Spectrometry-based Urinary Proteomics (epmc).pdf DeepDyve Pubget Overpricing