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10.1101/gad.279414.116

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C4888843!4888843!27198225
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suck abstract from ncbi


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pmid27198225      Genes+Dev 2016 ; 30 (10): 1240-50
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  • Physiological restraint of Bak by Bcl-xL is essential for cell survival #MMPMID27198225
  • Lee EF; Grabow S; Chappaz S; Dewson G; Hockings C; Kluck RM; Debrincat MA; Gray DH; Witkowski MT; Evangelista M; Pettikiriarachchi A; Bouillet P; Lane RM; Czabotar PE; Colman PM; Smith BJ; Kile BT; Fairlie WD
  • Genes Dev 2016[May]; 30 (10): 1240-50 PMID27198225show ga
  • Lee et al. describe a mutation in mouse and human Bak that specifically disrupts its interaction with the prosurvival protein Bcl-xL. In vivo, loss of Bcl-xL binding to Bak led to significant defects in T-cell and blood platelet survival.
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