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10.1101/gad.276022.115

http://scihub22266oqcxt.onion/10.1101/gad.276022.115
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C4888842!4888842!27198227
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suck abstract from ncbi


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pmid27198227      Genes+Dev 2016 ; 30 (10): 1224-39
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  • HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP #MMPMID27198227
  • Noh JH; Kim KM; Abdelmohsen K; Yoon JH; Panda AC; Munk R; Kim J; Curtis J; Moad CA; Wohler CM; Indig FE; de Paula W; Dudekula DB; De S; Piao Y; Yang X; Martindale JL; de Cabo R; Gorospe M
  • Genes Dev 2016[May]; 30 (10): 1224-39 PMID27198227show ga
  • Noh et al. found two RNA-binding proteins (RBPs)?HuR and GRSF1?that associated with the nuclear DNA-encoded lncRNA RMRP and mobilized it to mitochondria. In cultured human cells, HuR bound RMRP in the nucleus and mediated its CRM1-dependent export to the cytosol. After RMRP was imported into mitochondria, GRSF1 bound RMRP and increased its abundance in the matrix.
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