J Thromb Haemost 2015[Jun]; 13 (Suppl 1): S17-25 PMID26149019show ga
During the past decade, advanced techniques in structural biology have provided atomic level information on the platelet integrin ?IIb?3 activation mechanism that results in it adopting a high-affinity ligand-binding conformation(s). This review focuses on advances in imaging intact ?IIb?3 in a lipid bilayer in the absence of detergent and new structural insights into the changes in the ligand-binding pocket with receptor activation and ligand binding. It concludes with descriptions of novel therapeutic ?IIb?3 antagonists being developed based on an advanced knowledge of the receptor?s structure.