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10.4103/0972-2327.179979 http://scihub22266oqcxt.onion/10.4103/0972-2327.179979 C4888677!4888677!27293325     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Indian+Acad+Neurol 2016 ; 19 (2): 169-74 Nephropedia Template TP {{tp|p=27293325|t=2016. Prions, prion-like prionoids, and neurodegenerative disorders |pdf=|usr=}}{{27293325}} gab.com Text Prions, prion-like prionoids, and neurodegenerative disorders JO: Ann Indian Acad Neurol http://www.kidney.de/pget.php?&tw=1&pmid=27293325 #FOAvip Prion diseases or transmissible spongiform encephalopathies are fatal neurodegenerative diseases characterized by the aggregation and deposition of the misfolded prion protein in the brain. ?-synuclein (?-syn)-associated multiple system atrophy has been recently shown to be caused by a bona fide ?-syn prion strain. Several other misfolded native proteins such as ?-amyloid, tau and TDP-43 share some aspects of prions although none of them is shown to be transmissible in nature or in experimental animals. However, these prion-like ?prionoids? are causal to a variety of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The remarkable recent discovery of at least two new ?-syn prion strains and their transmissibility in transgenic mice and in vitro cell models raises a distinct question as to whether some specific strain of other prionoids could have the capability of disease transmission in a manner similar to prions. In this overview, we briefly describe human and other mammalian prion diseases and comment on certain similarities between prion and prionoid and the possibility of prion-like transmissibility of some prionoid strains. Twit Text FOAVip Prions, prion-like prionoids, and neurodegenerative disorders ????Ann Indian Acad Neurol http://www.kidney.de/pget.php?&tw=1&pmid=27293325 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27293325 #FOAvip English Wikipedia <ref>{{Cite pmid|27293325}}</ref> Prions, prion-like prionoids, and neurodegenerative disorders #MMPMID27293325 Verma A Ann Indian Acad Neurol 2016[Apr]; 19 (2): 169-74 PMID27293325show ga Prion diseases or transmissible spongiform encephalopathies are fatal neurodegenerative diseases characterized by the aggregation and deposition of the misfolded prion protein in the brain. ?-synuclein (?-syn)-associated multiple system atrophy has been recently shown to be caused by a bona fide ?-syn prion strain. Several other misfolded native proteins such as ?-amyloid, tau and TDP-43 share some aspects of prions although none of them is shown to be transmissible in nature or in experimental animals. However, these prion-like ?prionoids? are causal to a variety of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The remarkable recent discovery of at least two new ?-syn prion strains and their transmissibility in transgenic mice and in vitro cell models raises a distinct question as to whether some specific strain of other prionoids could have the capability of disease transmission in a manner similar to prions. In this overview, we briefly describe human and other mammalian prion diseases and comment on certain similarities between prion and prionoid and the possibility of prion-like transmissibility of some prionoid strains. äPrions, prion-like prionoids, and neurodegenerative disorders (epmc).pdf DeepDyve Pubget Overpricing