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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 EMBO+J 2016 ; 35 (11): 1158-9 Nephropedia Template TP
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Scanning for a unified model for translational repression by microRNAs #MMPMID27099299
Nishimura T; Fabian MR
EMBO J 2016[Jun]; 35 (11): 1158-9 PMID27099299show ga
MicroRNAs (miRNAs) silence target mRNAs by inhibiting translation and subsequently initiating mRNA decay. The mechanism by which miRNAs silence translation is still poorly understood, with a number of competing models proposed. In this issue of The EMBO Journal, Kuzuo?lu?Öztürk et al (2016) investigated miRNA silencing in human and insect cells. Their data support a model whereby miRNAs inhibit translation initiation. However, in contrast to several recent reports, their data suggest that translational inhibition is independent of 43S ribosomal subunit scanning, eIF4A translation factor activity, and 5?UTR secondary structure.