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10.15252/embj.201694324

http://scihub22266oqcxt.onion/10.15252/embj.201694324
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C4888241!4888241!27099299
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suck abstract from ncbi


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pmid27099299      EMBO+J 2016 ; 35 (11): 1158-9
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  • Scanning for a unified model for translational repression by microRNAs #MMPMID27099299
  • Nishimura T; Fabian MR
  • EMBO J 2016[Jun]; 35 (11): 1158-9 PMID27099299show ga
  • MicroRNAs (miRNAs) silence target mRNAs by inhibiting translation and subsequently initiating mRNA decay. The mechanism by which miRNAs silence translation is still poorly understood, with a number of competing models proposed. In this issue of The EMBO Journal, Kuzuo?lu?Öztürk et al (2016) investigated miRNA silencing in human and insect cells. Their data support a model whereby miRNAs inhibit translation initiation. However, in contrast to several recent reports, their data suggest that translational inhibition is independent of 43S ribosomal subunit scanning, eIF4A translation factor activity, and 5?UTR secondary structure.
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